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Acute and subacute effects of diazepam on human performance: comparison of plain tablet and controlled release capsule.

Author: MattilaM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

DZ-CR capsules produced less acute psychomotor impairment than DZ tablets and had a steadier pharmacokinetic profile, suggesting it is a better option for the long-term treatment of anxiety.
Paper Details　
Original Abstract of the Article :
The psychomotor performance of 9 healthy volunteers was measured in a randomized, double-blind, cross-over manner after single doses (Day 1) and one-week maintenance (Day 8) with diazepam given in uncoated tablets (DZ) or in controlled-release capsule (DZ-CR). The performance was measured objectivel...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0773.1988.tb00970.x

データ提供：米国国立医学図書館（NLM）

The Curious Case of Diazepam: A Camel's Tale of Psychomotor Effects

The world of psychopharmacology is a fascinating one, with drugs like diazepam having both therapeutic and potentially impairing effects. This research delves into the effects of diazepam on human performance, exploring the differences between immediate-release and controlled-release formulations. The researchers used a controlled trial design to assess the impact of diazepam on both objective and subjective measures of performance.

A Controlled Release Approach to Diazepam: A Camel's Perspective

The study found that the controlled-release formulation of diazepam had fewer acute psychomotor impairments compared to the immediate-release formulation. This suggests that the controlled-release approach may be more suitable for long-term treatment of anxiety, as it provides a more sustained and consistent effect. This is a significant finding, as it emphasizes the importance of drug delivery strategies in optimizing therapeutic outcomes.

Navigating the Sands of Anxiety: A Camel's Advice

If you're prescribed diazepam, it's important to discuss with your doctor the best formulation for your needs. You may want to consider the potential side effects and impact on your daily activities, especially if your work or hobbies require sharp cognitive skills. The desert of anxiety can be challenging, but understanding the nuances of medication can help you find your oasis.

Dr.Camel's Conclusion

This research highlights the importance of understanding drug delivery mechanisms and their impact on therapeutic outcomes. It sheds light on the potential benefits of controlled-release formulations in minimizing the acute effects of medications like diazepam while maximizing their therapeutic potential.

Date :
  1. Date Completed 1989-05-02
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

3070520

DOI: Digital Object Identifier

10.1111/j.1600-0773.1988.tb00970.x

Related Literature

Article Analysis
・Effects of diazepam
SNS
PICO Info
in preparation
Languages

English

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