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Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling.

Author: GarcíaCristina B, GinerBeatriz, LombaLaura, RibateM Pilar, ZuriagaEstefanía

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the acute toxicity of five drugs (diphenhydramine, gentamicin, tobramycin, enalapril, and lidocaine) to zebrafish embryos. It found that the drugs were generally safe at concentrations found in the natural environment, but some showed teratogenic effects at lower concentrations. The study suggests a low environmental toxicological risk but highlights the need for further investigation of teratogenic potential.
Paper Details　
Original Abstract of the Article :
The final fate of many drugs is release into the natural aquatic environment. It is necessary to assess the toxicity caused by this situation and the associated concerns for human beings. Zebrafish (Danio rerio) is a common biomodel used to assess toxicity in aquatic environments. The zebrafish embr...See full text at original site
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引用元：
https://doi.org/10.1016/j.ecoenv.2019.01.081

データ提供：米国国立医学図書館（NLM）

Zebrafish Embryos: A Window into Drug Toxicity

The study of drug toxicity is essential for ensuring the safety of both humans and the environment. This research delves into the world of aquatic toxicology, using zebrafish embryos as a model to assess the toxicity of various drugs. Zebrafish embryos are incredibly sensitive to environmental changes, making them ideal for investigating the effects of substances released into the aquatic environment.

Investigating Drug Effects on Zebrafish Embryos: A Safeguard for the Environment

The study found that several drugs, including diphenhydramine, gentamicin, and lidocaine, showed both lethal and sublethal effects on zebrafish embryos. However, the researchers also found that the concentrations at which these effects were observed were much higher than those typically found in natural environments. This suggests a low environmental toxicological risk.

Navigating the Waters of Drug Safety: A Cautious Approach

While the overall environmental risk from these drugs may be low, it is important to note that some drugs, like caffeine, diphenhydramine, and lidocaine, caused teratogenic effects on zebrafish embryos at lower concentrations than the LC50 (the concentration at which 50% of the embryos die). This means that even at relatively low concentrations, these drugs can disrupt embryonic development.

Dr. Camel's Conclusion

This research serves as a reminder that even seemingly harmless substances can have unexpected effects on the environment. By using zebrafish embryos as a model system, we can gain valuable insights into drug toxicity and identify potential risks before they impact the delicate ecosystem of our aquatic environments.

Date :
  1. Date Completed 2019-04-03
  2. Date Revised 2019-04-03
Further Info :

Pubmed ID

30711857

DOI: Digital Object Identifier

10.1016/j.ecoenv.2019.01.081

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Languages

English

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