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Cinacalcet therapy in an infant with an R185Q calcium-sensing receptor mutation causing hyperparathyroidism: a case report and review of the literature.

Author: FormanThomas E, NallyLaura M, NiemiAnna-Kaisa, PrahaladPriya, ShiRun Zhang

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This case report describes the successful use of cinacalcet therapy in a newborn with severe hyperparathyroidism caused by a de novo mutation in the calcium-sensing receptor gene. Cinacalcet effectively controlled serum calcium, phosphorus, and parathyroid hormone levels without side effects.
Paper Details　
Original Abstract of the Article :
Background Neonatal severe hyperparathyroidism (NSHPT) is commonly treated with either parathyroidectomy or pharmacologic agents with varying efficacy and numerous side effects. Reports of using cinacalcet for NSHPT have increased, however, the effective dose for pediatric patients from the onset of...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30730839

データ提供：米国国立医学図書館（NLM）

Cinacalcet: A Potential Solution in the Desert of Neonatal Hyperparathyroidism

Neonatal severe hyperparathyroidism (NSHPT) is a rare but serious condition that affects infants. This study reports a case of an infant with NSHPT who received treatment with cinacalcet, a medication that regulates calcium levels. The infant's serum calcium, phosphorus, and parathyroid hormone levels were effectively controlled with cinacalcet therapy. The study also reviews the literature on cinacalcet use in NSHPT, highlighting its potential as a treatment option for this condition.

Cinacalcet: A Hopeful Approach for Neonatal Hyperparathyroidism

This case report provides encouraging evidence for the use of cinacalcet in treating NSHPT. The medication effectively controlled the infant's hormone levels without any side effects. Further research is needed to confirm these findings and establish optimal dosing for infants.

Navigating the Desert of Childhood Disease

Childhood diseases can be challenging to manage, and NSHPT is no exception. This study highlights the potential of cinacalcet as a treatment option for this rare condition. Continued research is essential for developing safe and effective therapies for children with NSHPT.

Dr.Camel's Conclusion

The desert of childhood disease can be a difficult and uncertain landscape for parents and healthcare providers. This study offers a ray of hope for infants with NSHPT, demonstrating the potential of cinacalcet as a treatment option. Further research is needed to ensure its safety and efficacy, but this study provides a valuable starting point.

Date :
  1. Date Completed 2019-06-21
  2. Date Revised 2021-02-13
Further Info :

Pubmed ID

30730839

DOI: Digital Object Identifier

jpem-2018-0307

Related Literature

Article Analysis
・Side Effects of cinacalcet
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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