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Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio.

Author: BousemaTeun, BradleyJohn, ChurcherThomas S, DelvesMichael, DiawaraHalimatou, DickoAlassane, DrakeleyChris, GoslingRoly, MahamarAlmahamoudou, RohMichelle, SoumaréHarouna M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Gametocyte density and sex ratio predict the proportion of mosquitoes infected after feeding on blood of patients receiving nongametocytocidal drugs. Primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, requiring mosquito feeding experiments to demonstrate their early transmission-blocking effects.
Paper Details　
Original Abstract of the Article :
Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763632/

データ提供：米国国立医学図書館（NLM）

Understanding Malaria Transmission: The Effects of Primaquine and Methylene Blue

Malaria, a mosquito-borne disease, poses a significant health threat in many parts of the world. This study investigates the transmission-blocking effects of primaquine and methylene blue, two drugs used to treat malaria. It's like exploring the desert landscape of malaria transmission, seeking to understand how these drugs can interrupt the cycle of infection.

Blocking Transmission: A Key to Eradication

The researchers found that primaquine and methylene blue effectively sterilize malaria parasites, preventing them from being transmitted to mosquitoes. It's like creating a barrier in the desert, blocking the pathway for the disease to spread.

Continued Research and Development

The researchers emphasize the importance of continued research into transmission-blocking drugs to further reduce the burden of malaria. It's like expanding and strengthening the barrier, ensuring a more effective defense against this debilitating disease.

Dr.Camel's Conclusion

This study provides valuable insights into the transmission-blocking effects of primaquine and methylene blue. It's a reminder that the desert of malaria transmission is vast and complex, requiring innovative approaches and persistent research to ultimately eradicate this disease.

Date :
  1. Date Completed 2020-09-14
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

30753355

DOI: Digital Object Identifier

PMC6763632

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Languages

English

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