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Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.

Author: GillenMichael, KerrBradley, LeeCaroline A, ShenZancong, ValdezShakti, WallachKathleen, WilsonDavid M

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lesinurad is a drug used to treat gout. This study investigated whether lesinurad interacts with warfarin, a blood thinner. The results showed no significant interaction, suggesting that patients can safely take both medications together.
Paper Details　
Original Abstract of the Article :
Lesinurad is a selective uric acid reabsorption inhibitor approved for use in combination with xanthine oxidase inhibitors for the treatment of hyperuricemia associated with gout. In vitro, lesinurad was shown to be a weak inhibitor of cytochrome P450 (CYP)2C9 and a weak inducer of CYP3A4. Warfarin ...See full text at original site
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引用元：
https://doi.org/10.1002/cpdd.662

データ提供：米国国立医学図書館（NLM）

Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers

This study explores the potential drug interactions between [lesinurad], a medication used to treat [hyperuricemia] associated with [gout], and [warfarin], a common anticoagulant. The researchers investigated the effects of [lesinurad] on the pharmacokinetics and pharmacodynamics of [warfarin] in healthy volunteers. Their findings are crucial for understanding the safety and efficacy of combining these medications.

No Significant Drug Interactions

The study's results demonstrate that [no clinically significant drug-drug interaction] was observed when [warfarin] was administered in the presence of [lesinurad]. This finding is reassuring for healthcare professionals and patients who may need to use both medications concurrently. The study emphasizes the importance of careful pharmacokinetic and pharmacodynamic evaluations when prescribing medications that may interact with each other.

Managing Gout and Anticoagulation

The findings of this study provide valuable information for clinicians managing patients with both [gout] and the need for [anticoagulation]. The study's findings suggest that [lesinurad] and [warfarin] can be safely used together, facilitating the management of these conditions without significant concerns about drug interactions.

Dr. Camel's Conclusion

Navigating the complexities of drug interactions is like navigating a desert of potential complications. This research offers a valuable oasis of knowledge, demonstrating that [lesinurad] and [warfarin] can be safely used together. This knowledge is essential for making informed treatment decisions and ensuring the well-being of patients.

Date :
  1. Date Completed 2020-07-13
  2. Date Revised 2020-07-13
Further Info :

Pubmed ID

30758919

DOI: Digital Object Identifier

10.1002/cpdd.662

Related Literature

Article Analysis
・Effects of lesinurad
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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