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The dilemma of metastatic medullary thyroid carcinoma: when to start systemic treatment.
Author: AlfieriSalvatore, BergaminiCristiana, CalaresoGiuseppina, GranataRoberta, LocatiLaura Deborah, OrlandiEster, SianoMarco
Original Abstract of the Article :
Label="PURPOSE" NlmCategory="OBJECTIVE">Two tyrosine kinase inhibitors (TKIs), vandetanib and cabozantinib, have been approved for recurrent/metastatic (R/M) medullary thyroid carcinoma (MTC). To date, it is still debated when and which TKI has to be started in R/M MTC patients. This is due to 1) TK...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1177/0300891619829571
データ提供:米国国立医学図書館(NLM)
The Evolving Landscape of Medullary Thyroid Carcinoma Treatment
This case study highlights the [challenges] in treating [metastatic medullary thyroid carcinoma (MTC)]. The availability of [tyrosine kinase inhibitors (TKIs)] has ushered in a new era of treatment, but determining [when and which TKI] to use remains a complex question. This study sheds light on the [unique challenges] presented by MTC, particularly the [discordant disease behavior] observed in this case, where some tumors regressed spontaneously while others progressed.
Navigating the Sand Dunes of Treatment Decisions
The authors raise important questions about the [optimal timing for starting TKIs] in MTC patients. These questions are akin to navigating a shifting sand dune landscape - the terrain is constantly changing, and the best path forward is not always clear. The study highlights the need for [individualized treatment plans] that consider the [specific characteristics] of each patient's disease.
A New Oasis of Treatment Options
This case study emphasizes the evolving nature of [MTC treatment]. With new therapies emerging, it is essential to stay abreast of the latest advancements and adapt treatment strategies accordingly. This is like discovering a new oasis in the desert – it requires careful exploration and a willingness to embrace new knowledge.
Dr.Camel's Conclusion
This study serves as a reminder that [treating MTC] requires a nuanced approach that considers the [individual characteristics] of each patient. It is a testament to the ever-changing landscape of cancer treatment, where new therapies are constantly emerging, but careful consideration and personalized strategies are crucial for navigating the desert of disease.
Date :
- Date Completed 2020-01-22
- Date Revised 2022-04-12
Further Info :
Related Literature
English
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