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Renal Effects of Crizotinib in Patients With ALK-Positive Advanced NSCLC.

Author: CamidgeD Ross, KimElizabeth E, LewisIona, PolliAnna, UsariTiziana, WilnerKeith D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Crizotinib, a drug for anaplastic lymphoma kinase-positive advanced non-small cell lung cancer (NSCLC), led to a decrease in creatinine-based estimates of renal function mostly during the first two weeks of treatment. However, these changes were largely reversible following treatment discontinuation, suggesting that the effect may be on creatinine secretion rather than true nephrotoxicity.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: We retrospectively analyzed the effects of crizotinib on serum creatinine and creatinine-based estimated glomerular filtration rate (eGFR) in patients with anaplastic lymphoma kinase-positive advanced NSCLC across four trials (NCT00585195, NCT00932451, NCT00932893, and NCT01154140). M...See full text at original site
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引用元：
https://doi.org/10.1016/j.jtho.2019.02.015

データ提供：米国国立医学図書館（NLM）

Crizotinib: Navigating the Renal Landscape

Cancer treatment is like a vast desert, filled with challenges and potential side effects. This research explores the renal effects of crizotinib, a targeted therapy for anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). The researchers are like skilled desert navigators, carefully assessing the impact of this medication on the kidneys.

A Transient Storm: Understanding the Impact

The study, like a detailed map of a desert region, meticulously analyzes the changes in serum creatinine and estimated glomerular filtration rate (eGFR) in patients receiving crizotinib. It's like observing a brief sandstorm, with a temporary impact on the landscape. The researchers found that crizotinib caused a transient decline in renal function, primarily during the first two weeks of treatment.

A Navigable Path: Toward Effective Treatment

This research is like a compass guiding us through the potential side effects of crizotinib. It's a reminder that even with powerful medications, careful monitoring and individualized treatment plans are crucial to ensure the safety and well-being of patients. The study's findings provide valuable information for healthcare providers, allowing them to manage crizotinib treatment effectively and minimize the risk of renal complications.

Dr. Camel's Conclusion

This research is like a desert journey, revealing the transient impact of crizotinib on renal function. It underscores the importance of vigilant monitoring and careful management to ensure the safe and effective use of this powerful medication for patients with ALK-positive advanced NSCLC.

Date :
  1. Date Completed 2020-07-21
  2. Date Revised 2020-07-21
Further Info :

Pubmed ID

30822515

DOI: Digital Object Identifier

10.1016/j.jtho.2019.02.015

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Article Analysis
・Effects of crizotinib
SNS
PICO Info
in preparation
Languages

English

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