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Prevalence of baseline NS3 resistance-associated substitutions (RASs) on treatment with protease inhibitors in patients infected with HCV genotype 1.
Author: Brandão-MelloCarlos Eduardo, CostaVanessa Duarte, DelvauxNathália, LampeElisabeth, NunesEstevão Portela, de SousaPaulo Sérgio Fonseca, de Souza RodriguesLia Laura Lewis Ximenez, do Amaral MelloFrancisco Campello
Original Abstract of the Article :
Treatment for hepatitis C has evolved significantly with the licensing of direct-acting antiviral drugs (DAAs). However, one of the limiting factors of the effectiveness of antiviral therapy with protease inhibitors (PIs) is the emergence of resistance caused by point mutations. The aim of this stud...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinre.2019.02.009
データ提供：米国国立医学図書館（NLM）
The Battle Against HCV: A Look at NS3 Resistance
Hepatitis C virus (HCV) infection is a global health challenge, affecting millions worldwide. The emergence of direct-acting antiviral drugs (DAAs) has revolutionized the treatment landscape, but the development of resistance remains a significant hurdle. This study explores the prevalence of resistance-associated substitutions (RASs) in the HCV NS3 gene, a key protein involved in viral replication, before the initiation of treatment with simeprevir, a protease inhibitor.
The study found that NS3 RASs are prevalent in patients with genotype 1 HCV infection, highlighting the importance of understanding resistance patterns to tailor treatment strategies. The researchers identified the need for continued vigilance in monitoring for resistance and developing new approaches to combat this challenge.
Navigating the Sands of HCV Resistance
The presence of NS3 RASs before treatment with simeprevir indicates that resistance is a significant factor to consider when treating HCV infection. The researchers found that resistance patterns are closely linked to HCV genotype, emphasizing the need for genotype-specific treatment strategies. This study underscores the importance of ongoing surveillance and development of new drugs to overcome this obstacle.
A New Path in the HCV Desert
The discovery of NS3 RASs in HCV genotype 1 patients highlights the need for ongoing research and development of new treatment strategies to combat resistance. This study serves as a reminder of the dynamic nature of HCV infection and the importance of continued vigilance in this field.
Dr. Camel's Conclusion
The fight against HCV infection is an ongoing battle through a vast desert of challenges. This study sheds light on the problem of resistance, an elusive sandstorm that can quickly derail treatment efforts. By understanding the patterns of resistance, we can develop more effective strategies for navigating the complex landscape of HCV infection and achieving a lasting cure.
Date :
- Date Completed 2020-10-15
- Date Revised 2020-10-15
Further Info :
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