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c-Fos expression response to olanzapine, amisulpride, aripiprazole, and quetiapine single administration in the rat forebrain: Effect of a mild stress preconditioning.

Author: KissAlexander, KoprdovaRomana, OsackaJana, PecenakJan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of four atypical antipsychotics (olanzapine, amisulpride, aripiprazole, and quetiapine) on the activity of cells in different forebrain areas of rats. The study found that all four drugs increased c-Fos expression in these areas, but the effects were modified by preconditioning with mild stress. These findings suggest that these drugs may have different effects depending on the presence of stress.
Paper Details　
Original Abstract of the Article :
Antipsychotics have been shown to stimulate different forebrain areas, whereas some of them are sensitive to stress. In the present study, effect of a single administration of olanzapine (OLA), amisulpride (AMI), aripiprazole (ARI), and quetiapine (QUE) on the activity of cells in the striatal dorso...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuint.2019.03.015

データ提供：米国国立医学図書館（NLM）

Olanzapine, Amisulpride, Aripiprazole, and Quetiapine: Examining the Effects of Antipsychotics on Brain Activity

This research delves into the neurobiological effects of atypical antipsychotics, specifically examining the impact of olanzapine, amisulpride, aripiprazole, and quetiapine on brain activity in rats. The study explored the expression of c-Fos protein, a marker of neuronal activity, in various brain regions following single administrations of these antipsychotics. The researchers also investigated the influence of mild stress preconditioning on the effects of these medications. The findings suggest that these antipsychotics can influence brain activity in different ways, depending on the specific drug and the presence of stress. The research provides insights into the complex neurobiological mechanisms underlying the actions of atypical antipsychotics.

The Complex Impact of Antipsychotics on Brain Activity

The study revealed that atypical antipsychotics can stimulate different brain regions, influencing neuronal activity in a drug-specific manner. Additionally, the research highlights the importance of considering the impact of stress in understanding the effects of these medications. This research provides a deeper understanding of the complex interplay between antipsychotics, brain activity, and stress.

The Health Implications and Practical Applications

This research is crucial for understanding the neurobiological actions of atypical antipsychotics, allowing for more targeted and effective treatment strategies for mental health conditions. By understanding the impact of these medications on different brain regions and how stress influences their effects, clinicians can make more informed decisions about treatment options and potentially minimize adverse side effects.

Dr.Camel's Conclusion

This research, like a desert expedition revealing new secrets, sheds light on the intricate relationship between antipsychotics and brain activity. It's a reminder that understanding the complexity of these medications is essential for developing effective and safe treatments for mental health conditions.

Date :
  1. Date Completed 2019-12-10
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

30905743

DOI: Digital Object Identifier

10.1016/j.neuint.2019.03.015

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Languages

English

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