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Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats.
Author: AlvesGilberto, FalcãoAmílcar, RodriguesMárcio, VenturaSandra
Original Abstract of the Article :
Garcinia cambogia supplements are widely used for weight loss. Knowing that epilepsy patients are at greater risk of developing overweight/obesity, the investigation of herb-drug interactions involving antiepileptic drugs of narrow therapeutic index is fully justified. This work was planned to asses...See full text at original site
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引用元：
https://doi.org/10.1016/j.fct.2019.03.051
データ提供：米国国立医学図書館（NLM）
Garcinia Cambogia and Lamotrigine: Exploring Potential Interactions
Garcinia cambogia, a tropical fruit, is widely used as a weight loss supplement. However, little is known about its potential interactions with medications, particularly those with narrow therapeutic indexes like lamotrigine, an antiepileptic drug. This study investigated the pharmacokinetic interactions between garcinia cambogia extract and lamotrigine in rats. The results showed that while co-administration of garcinia cambogia extract and lamotrigine had no significant impact, pre-treatment with garcinia cambogia extract for 14 days resulted in a slight decrease in lamotrigine's systemic exposure. These findings suggest that while garcinia cambogia may have a minor impact on lamotrigine's pharmacokinetics, the clinical implications are likely minimal.
Navigating Herb-Drug Interactions
This study underscores the importance of considering potential interactions between herbal supplements and medications. While garcinia cambogia may have a limited impact on lamotrigine, this study highlights the need for further research to understand the potential interactions between herbal supplements and medications, particularly those with narrow therapeutic indexes.
A Balancing Act: Herbal Supplements and Medications
Just as a camel adapts to the desert environment by balancing its water intake, we must be cautious about the potential interactions between herbal supplements and medications. This study emphasizes the need for vigilance and consultation with healthcare professionals when considering herbal supplements, ensuring they are safe and effective for individual needs.
Dr. Camel's Conclusion
The study on the interaction between garcinia cambogia extract and lamotrigine provides valuable insights into the potential for herb-drug interactions. While the findings suggest a minor impact on lamotrigine's pharmacokinetics, further research is warranted to fully understand the complexities of these interactions.
Date :
- Date Completed 2019-07-22
- Date Revised 2019-07-22
Further Info :
Related Literature
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