Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice.

Author: AbbasiMehrnaz, HaoLei, KhanMd Shahjalal Hossain, ScottSheyenne, WangShu, WuDayong, YangYang, ZhaoLing, ZuYujiao

Paper Details 
Original Abstract of the Article :
Mirabegron, a <i>&#946;</i>3-adrenergic receptor agonist, has been shown to stimulate the activity of brown fat and increase the resting metabolic rate in humans. However, it is unknown whether mirabegron can reduce body weight and improve metabolic health. We investigated the antiobesity effects of...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530071/

データ提供:米国国立医学図書館(NLM)

Mirabegron: A New Oasis in the Desert of Obesity?

This research explores the potential [metabolic effects] of [mirabegron], a β3-adrenergic receptor agonist, for combating [obesity]. The authors investigated mirabegron's effects in vitro and in vivo, finding that it stimulated [uncoupling protein 1 (UCP1) expression] and promoted [browning of inguinal white adipose tissue (iWAT)]. In animal studies, mirabegron-treated mice exhibited lower body weight, reduced adiposity, and improved glucose tolerance and insulin sensitivity. The study suggests that mirabegron may offer potential benefits for managing obesity and related metabolic disorders.

A New Approach to Obesity: Harnessing the Power of Brown Fat

The study unveils the potential of mirabegron in promoting brown fat activity and improving metabolic health. The findings suggest that mirabegron could serve as a novel therapeutic agent for managing obesity and related metabolic disorders, offering a new approach to tackling this complex health challenge. It's like finding a new oasis in the desert, offering a refreshing and revitalizing solution to the challenging landscape of obesity.

Obesity Management: A Dr.Camel Perspective

As a physician, I am always searching for effective and safe ways to manage obesity. This research provides encouraging insights into the potential of mirabegron to promote brown fat activity and improve metabolic health. It's a reminder that exploring new avenues and innovative therapies is crucial for addressing this complex and growing health issue. Like a camel navigating a vast desert, we must embrace new strategies and explore uncharted territories to find solutions to the challenges of obesity.

Dr.Camel's Conclusion

This research suggests that mirabegron, a β3-adrenergic receptor agonist, may offer potential benefits for managing obesity and related metabolic disorders. The findings highlight the importance of exploring novel therapies that target brown fat activity and promote metabolic health.

Date :
  1. Date Completed 2019-12-30
  2. Date Revised 2020-06-02
Further Info :

Pubmed ID

30940691

DOI: Digital Object Identifier

PMC6530071

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Languages

English

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