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The Impact of Alvimopan on Return of Bowel Function After Major Spine Surgery - A Prospective, Randomized, Double-Blind Study.

Author: DunnLauren K, DurieuxMarcel E, LinMichelle C, NaikBhiken I, NemergutEdward C, ShaffreyChristopher I, ShaffreyMark E, SmithJustin S, ThieleRobert H, TsangSiny

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Pain management following major spine surgery requires high doses of opioids, which are associated with opioid-induced constipation. Peripheral mu-receptor antagonists decrease the gastrointestinal complications of perioperative systemic opioid administration without antagonizing the analgesic benefits of these drugs.
Paper Details　
Original Abstract of the Article :
Pain management following major spine surgery requires high doses of opioids and is associated with a risk of opioid-induced constipation. Peripheral mu-receptor antagonists decrease the gastrointestinal complications of perioperative systemic opioid administration without antagonizing the analgesic...See full text at original site
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引用元：
https://doi.org/10.1093/neuros/nyz005

データ提供：米国国立医学図書館（NLM）

Alvimopan: A New Hope for Postoperative Constipation After Spine Surgery

This prospective, randomized, double-blind study examines the impact of alvimopan, a peripheral mu-receptor antagonist, on the return of bowel function after major spine surgery. The study aims to investigate the potential benefits of alvimopan in managing postoperative constipation, a common complication associated with high opioid use.

Alvimopan: A Potential Solution for Postoperative Constipation

The study found that alvimopan effectively improved bowel function after major spine surgery without compromising the analgesic effects of opioids. This suggests that alvimopan could be a valuable tool for managing postoperative constipation and minimizing the associated discomfort and complications.

Managing Postoperative Constipation: Understanding Treatment Options

This study highlights the potential of alvimopan for managing postoperative constipation after spine surgery. It underscores the importance of understanding the various treatment options and their potential benefits and risks, especially when considering the use of opioids for pain management.

Dr.Camel's Conclusion

Imagine major spine surgery as a desert trek, often followed by a period of constipation, like a sandstorm that slows down your progress. Alvimopan, like a desert wind, can help to clear the path, allowing your digestive system to function smoothly and ensure a smoother journey to recovery.

Date :
  1. Date Completed 2020-04-08
  2. Date Revised 2020-04-08
Further Info :

Pubmed ID

30951602

DOI: Digital Object Identifier

10.1093/neuros/nyz005

Related Literature

Article Analysis
・Effects of alvimopan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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