Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study.

Author: AkkayaEnes, EvranŞevket, HanımoğluHakan, HatiboğluMustafa Aziz, KarataşErsin, KatarSalim, KaynarMehmet Yaşar, KoçyiğitAbdurrahim, SağlamMustafa Yasin, SeyithanoğluMehmet Hakan, ÇalışFatih, ÇevikSerdar

Paper Details 
Original Abstract of the Article :
Verapamil, a calcium-channel blocker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects. Although the effective results of nimodipine and nicardipine's intrathecal administration are we...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.wneu.2019.04.050

データ提供:米国国立医学図書館(NLM)

The Intricate Dance of Verapamil and Cerebral Vasospasm

Cerebral vasospasm, a condition characterized by a narrowing of blood vessels in the brain, is a serious complication that can lead to stroke. Researchers have been exploring the potential of calcium-channel blockers, such as verapamil, to treat this condition. This research delves into the use of intrathecal verapamil, an approach that involves directly delivering the medication into the spinal fluid. The study utilizes an experimental rat model to evaluate the vasodilator and neuroprotective effects of verapamil, using a subarachnoid hemorrhage model. This study offers a unique perspective on the potential therapeutic applications of verapamil for cerebral vasospasm, highlighting the need for further exploration to understand its efficacy and safety in humans.

Verapamil's Potential in Cerebral Vasospasm Treatment

This study's findings suggest that intrathecal verapamil may be a promising treatment option for cerebral vasospasm. However, it's crucial to note that this research was conducted in a rat model, and further investigation is needed to translate these findings to human patients. While verapamil has been shown to be effective in some situations, its potential side effects are a concern. The authors emphasized the need for careful and thorough research to determine the optimal dosage, administration method, and potential risks associated with intrathecal verapamil.

A Complex Puzzle in Cerebral Health

The effectiveness of verapamil in treating cerebral vasospasm highlights the intricate nature of this condition. This research underscores the need for comprehensive approaches to understand the underlying mechanisms of cerebral vasospasm and explore potential treatments. It's crucial to consider the potential risks and benefits of all treatment options, particularly when dealing with such a delicate part of the body as the brain. It's essential to consult with a qualified healthcare professional for any concerns or questions regarding cerebral vasospasm or its potential treatments.

Dr.Camel's Conclusion

This research is a step towards understanding the potential of verapamil for treating cerebral vasospasm. While the findings are promising, much more research is needed to understand its true impact on human health. Like the elusive shimmer of a mirage in the desert, the potential benefits of this treatment need careful investigation before they can be fully realized.
Date :
  1. Date Completed 2020-01-14
  2. Date Revised 2020-01-14
Further Info :

Pubmed ID

30980985

DOI: Digital Object Identifier

10.1016/j.wneu.2019.04.050

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.