Paper Details

  1. Home
  2. Paper Details

Neuroprotective effects of the second generation antipsychotics.

Author: ChenAlexander T, NasrallahHenry A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study reviewed the neuroprotective effects of second-generation antipsychotics (SGAs) compared to first-generation antipsychotics (FGAs). While FGAs have been associated with neurotoxicity in over 30 studies, SGAs have shown neuroprotective effects in several published studies.
Paper Details　
Original Abstract of the Article :
In contrast to over 30 studies reporting neurotoxicity associated with the first-generation antipsychotics (FGAs), several published studies have reported multiple neuroprotective effects associated with the second generation antipsychotics (SGAs). This prompted us to conduct a review of the reporte...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.schres.2019.04.009

データ提供：米国国立医学図書館（NLM）

Neuroprotective Effects of Second-Generation Antipsychotics: A Journey Through the Mind's Desert

Navigating the intricate desert of mental health conditions, particularly schizophrenia, is a challenging journey. The field of antipsychotics has undergone a transformative shift, with the emergence of second-generation antipsychotics (SGAs) offering a glimmer of hope. This research examines the neuroprotective potential of SGAs compared to their first-generation counterparts (FGAs), shedding light on the therapeutic landscape of mental health.

The authors' review delves into the vast scientific literature, highlighting the contrasting neurotoxicity associated with FGAs and the potential neuroprotective effects observed with SGAs. They meticulously analyze the reported mechanisms underlying these contrasting effects, revealing a fascinating interplay of neurobiology and medication.

A Glimpse into the Oasis of Neuroprotection: Rethinking Antipsychotics

This research suggests that the shift from FGAs to SGAs could represent a significant step towards a more neuroprotective approach to treating schizophrenia. It underscores the importance of continually evaluating the impact of medications on the brain and exploring new avenues for neuroprotective strategies.

Beyond the Sand Dunes of Mental Illness: Understanding Neuroprotection

This study reminds us that the brain is a complex desert landscape, and navigating its intricacies requires ongoing research and understanding. By unraveling the neuroprotective mechanisms of SGAs, researchers are paving the way for more effective and less harmful treatments for mental health conditions.

Dr. Camel's Conclusion

The authors' exploration of the neuroprotective potential of SGAs offers a hopeful glimpse into a future where treatments for mental health conditions are not only effective but also protective of the brain. This research serves as a reminder that the journey through the desert of mental illness is complex, but with continued research and innovation, we can discover new oases of hope.

Date :
  1. Date Completed 2020-08-03
  2. Date Revised 2020-08-03
Further Info :

Pubmed ID

30982644

DOI: Digital Object Identifier

10.1016/j.schres.2019.04.009

Related Literature

Article Analysis
・Side Effects of paliperidone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.