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Vitamin E and Selenium Reduce Prednisolone Side Effects in Rat Hearts.

Author: ArslanYusuf Kemal, BardasEbru, CetinNihal, CicekBetul, ErisirMine, PolatSeher, UsluGözde Atila

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

<b /> This study investigated the effects of vitamin E and Se supplementation on lipid peroxidation and antioxidative defense mechanisms in the hearts of rats treated with high doses of prednisolone. The study found that prednisolone significantly decreased the activity of antioxidant enzymes and increased lipid peroxidation, while supplementation with vitamin E and Se prevented these effects.
Paper Details　
Original Abstract of the Article :
<b /> Aim of this work was to determine the effects of dietary intake vitamin E and Se on lipid peroxidation (LPO) as Thiobarbituric acid reactive substances (TBARS) and on the antioxidative defense mechanisms in heart tissues of rats treated with high doses of prednisolone. 250 adult male Wistar r...See full text at original site
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引用元：
https://doi.org/10.1024/0300-9831/a000582

データ提供：米国国立医学図書館（NLM）

Vitamin E and Selenium: Potential Protectors Against Prednisolone Side Effects

The desert of drug side effects is a harsh landscape, often filled with unwanted consequences. This study explores the potential protective effects of vitamin E and selenium against the negative effects of prednisolone, a commonly used corticosteroid. The researchers found that vitamin E and selenium supplementation significantly reduced the increase in lipid peroxidation and the decrease in antioxidant enzyme activity in the hearts of rats treated with prednisolone. These findings suggest that vitamin E and selenium may offer a potential strategy to mitigate the adverse effects of prednisolone on the heart.

Vitamin E and Selenium: Potential Allies in Combating Prednisolone Side Effects

The study found that vitamin E and selenium supplementation significantly reduced the negative effects of prednisolone on the heart in rats. This suggests a potential for these supplements to mitigate the adverse effects of this medication. While further research is needed to confirm these findings in humans, the study offers a promising avenue for exploring strategies to reduce the risk of prednisolone-induced heart complications.

Understanding Prednisolone and its Side Effects

Prednisolone is a powerful corticosteroid that can effectively treat a variety of conditions, but it can also cause side effects, particularly on the heart. This study highlights the potential protective effects of vitamin E and selenium against these adverse effects. While further research is needed to confirm these findings in humans, the study offers a promising avenue for exploring strategies to reduce the risk of prednisolone-induced heart complications.

Dr. Camel's Conclusion

This study suggests that vitamin E and selenium may offer a potential strategy to mitigate the adverse effects of prednisolone on the heart. While further research is needed to confirm these findings in humans, the study offers a promising avenue for exploring strategies to reduce the risk of prednisolone-induced heart complications. As a wise camel, I always encourage you to consult with your doctor about any potential side effects of your medications and to discuss appropriate strategies for managing these effects.

Date :
  1. Date Completed 2023-10-06
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

30987549

DOI: Digital Object Identifier

10.1024/0300-9831/a000582

Related Literature

Article Analysis
・Side Effects of prednisolone
SNS
PICO Info
in preparation
Languages

English

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