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Efficacy and Safety of Mipomersen: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Author: CiceroArrigo F G, CorsiniAlberto, FerriNicola, FogacciFederica, RuscicaMassimiliano, TothPeter P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Mipomersen effectively reduced low-density lipoprotein cholesterol, total cholesterol, non-HDL-C, lipoprotein(a), apolipoprotein B, triglycerides, and very-low-density lipoprotein cholesterol, without affecting HDL-C levels. However, mipomersen therapy is associated with increased risk of discontinuation, injection-site reactions, hepatic steatosis, hepatic enzyme elevation, and flu-like symptoms.
Paper Details　
Original Abstract of the Article :
AIM: Our aim was to assess the efficacy and safety of mipomersen through a systematic review of the literature and a meta-analysis of the available clinical studies. METHODS: A systematic literature search in SCOPUS, PubMed Medline, ISI Web of Science and Google Scholar databases was conducted up t...See full text at original site
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引用元：
https://doi.org/10.1007/s40265-019-01114-z

データ提供：米国国立医学図書館（NLM）

Mipomersen: A Double-Edged Sword in Lipid Management

High cholesterol is a major health concern, and finding effective ways to manage it is crucial. This research investigates the [efficacy and safety] of [mipomersen], a drug designed to [reduce lipid levels]. The authors conduct a [systematic review and meta-analysis] of clinical trials, evaluating the impact of mipomersen on various lipid parameters, including [LDL cholesterol, total cholesterol, and triglycerides]. They also examine the potential [adverse effects] associated with this medication.

Mipomersen: A Mixed Bag of Benefits and Risks

The meta-analysis reveals that mipomersen is [effective] in reducing [LDL cholesterol, total cholesterol, non-HDL cholesterol, lipoprotein(a), apolipoprotein B, triglycerides, and very-low-density lipoprotein cholesterol] without affecting HDL-C levels. However, the study also highlights a [higher risk of discontinuation of treatment, injection-site reactions, hepatic steatosis, hepatic enzyme elevation, and flu-like symptoms] in patients receiving mipomersen.

Navigating Lipid Management: Weighing Benefits and Risks

This research underscores the importance of [carefully considering the potential risks and benefits] of any medication used to manage lipid levels. The authors emphasize the need for [individualized treatment decisions] based on each patient's specific needs and risk factors. By understanding the potential downsides of mipomersen, patients can work with their healthcare providers to make informed choices about their lipid management strategy.

Dr.Camel's Conclusion

This research, like a desert oasis offering both respite and potential hazards, reveals the complex nature of mipomersen. While it offers potential benefits for lowering lipid levels, its side effects require careful consideration. Ultimately, the decision to use mipomersen should be made in consultation with a healthcare professional, taking into account the individual patient's needs and risk profile.

Date :
  1. Date Completed 2019-11-27
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30989634

DOI: Digital Object Identifier

10.1007/s40265-019-01114-z

Related Literature

Article Analysis
・Effects of mipomersen injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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