Comparative effects of amiodarone and dronedarone treatments on cardiac function in a rabbit model.

Author: BoonhohWorakan, KijtawornratAnusak, SawangkoonSuwanakiet

Paper Details 
Original Abstract of the Article :
AIM: The objective of the study was to compare the effects of amiodarone (AM) and dronedarone (DR) on heart rate variability (HRV) and cardiac contractility in a rabbit model. MATERIALS AND METHODS: A total of 16 male New Zealand white rabbits were divided into two groups, treated either with AM or...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460874/

データ提供:米国国立医学図書館(NLM)

Amiodarone and Dronedarone: Unveiling the Heart's Rhythms

The world of [cardiac arrhythmias] is complex, and finding effective and safe treatments is a constant pursuit. This research focuses on the impact of two antiarrhythmic drugs, [amiodarone] and [dronedarone], on the heart's electrical activity and contractility. The researchers employed a [rabbit model] to compare the effects of these medications on heart rate variability (HRV) and cardiac contractility. They discovered that both amiodarone and dronedarone negatively impacted heart rate and HRV. This research provides valuable insights into the potential side effects of these drugs, particularly their impact on heart rate and cardiac function. It highlights the need for careful monitoring and individualized treatment approaches when prescribing these medications.

The Heartbeat of Research: Unmasking the Effects of Antiarrhythmic Drugs

The study found that both amiodarone and dronedarone significantly reduced heart rate and HRV, suggesting potential adverse effects on heart rhythm. These findings underscore the need for thorough evaluation of patients' cardiovascular health before prescribing these drugs and close monitoring during treatment. The research sheds light on the complex interplay between antiarrhythmic drugs and cardiac function.

A Heartbeat of Caution: Considerations for Patients

If you are taking amiodarone or dronedarone, it is essential to maintain open communication with your healthcare provider about any changes in your health status, particularly related to heart rhythm or other cardiovascular symptoms. This research emphasizes the importance of ongoing monitoring and personalized treatment plans to optimize the benefits and mitigate potential risks of these medications.

Dr. Camel's Conclusion

Navigating the complexities of the heart's rhythms requires careful consideration of medication effects. This research provides valuable insights into the impact of amiodarone and dronedarone on cardiac function, emphasizing the need for a balanced approach to treating cardiac arrhythmias, ensuring safety and efficacy.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

31040580

DOI: Digital Object Identifier

PMC6460874

Related Literature

SNS
PICO Info
in preparation
Languages

English

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