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Evolution of TEM-type extended-spectrum β-lactamases in Escherichia coli by cephalosporins.

Author: BirkegårdAnna Camilla, ClasenJulie, FolkessonAnders, GræsbøllKaare

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explored the molecular mechanisms behind the development of extended-spectrum β-lactamases (ESBLs), a type of antibiotic resistance enzyme, in response to exposure to different cephalosporin antibiotics. The study also investigated methods for detecting ESBLs in environmental samples.
Paper Details　
Original Abstract of the Article :
This study was conducted to examine the molecular mechanisms responsible for the evolution of TEM-type extended-spectrum β-lactamases (ESBLs) following selective pressure from four third-generation cephalosporins, namely ceftazidime, cefotaxime, ceftriaxone and ceftibuten. In addition, selective enr...See full text at original site
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引用元：
https://doi.org/10.1016/j.jgar.2019.03.010

データ提供：米国国立医学図書館（NLM）

Evolution of TEM-type Extended-Spectrum β-lactamases in Escherichia coli by Cephalosporins

This research explores the intriguing world of bacterial resistance, focusing on the evolution of TEM-type extended-spectrum β-lactamases (ESBLs) in Escherichia coli. The authors meticulously investigated the molecular mechanisms behind the development of resistance to four third-generation cephalosporins: ceftazidime, cefotaxime, ceftriaxone, and ceftibuten. Their findings reveal the complex interplay between antibiotic pressure and bacterial adaptation, providing valuable insights into the ongoing battle against antibiotic resistance.

Antibiotic Resistance: A Battle in the Desert

The study highlights the complex mechanisms behind antibiotic resistance, revealing how bacteria adapt and evolve in the face of antibiotic pressure. The researchers identified specific molecular changes that contribute to the development of ESBLs, providing a deeper understanding of the evolutionary process. This knowledge can inform the development of new strategies to combat antibiotic resistance.

Combating Resistance: A Race Against Time

This study underscores the critical importance of understanding the mechanisms behind antibiotic resistance. The authors emphasize the need for ongoing research to develop new antibiotics and strategies to combat the growing threat of resistant bacteria. This is a race against time, as antibiotic resistance continues to emerge and spread.

Dr.Camel's Conclusion

Imagine the desert as a vast and ever-changing landscape, where bacteria constantly adapt and evolve. This research highlights the intricate mechanisms behind antibiotic resistance, revealing how bacteria can overcome even the most potent antibiotics. Understanding these mechanisms is crucial in our ongoing battle against antibiotic resistance. The researchers are like explorers mapping this ever-shifting desert, seeking to outwit the relentless forces of bacterial evolution.
Date :
  1. Date Completed 2020-07-20
  2. Date Revised 2020-07-20
Further Info :

Pubmed ID

31048029

DOI: Digital Object Identifier

10.1016/j.jgar.2019.03.010

Related Literature

Article Analysis
・Effects of ceftibuten
SNS
PICO Info
in preparation
Languages

English

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