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Inhibition of N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder tumor in rats by alpha-difluoromethylornithine.

Author: KawaharaM, MatsuhashiT, MatsushimaM, TajimaM, YagishitaT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

DFMO significantly reduced the incidence, mean number, and total size of bladder tumors in rats induced by BBN. The only observed side effect was alopecia.
Paper Details　
Original Abstract of the Article :
The therapeutic effects of alpha-difluoromethylornithine (DFMO) on rats with bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were examined. Eight-week-old male Wistar rats were given 0.05% BBN in their drinking water for a period of 4 weeks. Therapy (0.1% DFMO in their drinkin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3107357

データ提供：米国国立医学図書館（NLM）

Alpha-Difluoromethylornithine's Effects on Bladder Tumors

This study takes us on a journey through the vast desert of [oncology], exploring the potential of [alpha-difluoromethylornithine (DFMO)] to inhibit [bladder tumor] growth in rats. It's like discovering a new plant in the desert that could potentially help combat a disease. The researchers investigated the effects of [DFMO] on rats with [bladder tumors] induced by [N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)]. They found that [DFMO] significantly reduced the [incidence], [number], and [size] of [bladder tumors] in this model. This discovery suggests that [DFMO] may have potential as a therapeutic agent for treating [bladder cancer].

DFMO Shows Promise in Inhibiting Bladder Tumor Growth

This study provides encouraging evidence for the potential of [DFMO] as a treatment for [bladder cancer]. They found that [specify the main findings]. This discovery could pave the way for new and more effective treatment options for patients with [bladder cancer].

Navigating the Desert of Bladder Cancer Treatment

This study helps us navigate the desert of [bladder cancer] treatment by highlighting the potential of [DFMO] as a promising therapeutic agent. It's important to remember that every case of [bladder cancer] is unique, like a unique sand dune in a vast desert. This study provides valuable insights into the potential of [DFMO] to inhibit [bladder tumor] growth and encourages further research to fully explore its potential for treating [bladder cancer].

Dr.Camel's Conclusion

This study offers promising insights into the potential of [alpha-difluoromethylornithine (DFMO)] as a therapeutic agent for treating [bladder cancer]. The researchers demonstrated that [DFMO] effectively reduced the [incidence], [number], and [size] of [bladder tumors] in rats. This discovery warrants further investigation into the potential of [DFMO] for treating [bladder cancer] in humans and could contribute to the development of new and more effective treatment options for this challenging disease.
Date :
  1. Date Completed 1987-06-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3107357

DOI: Digital Object Identifier

3107357

Related Literature

Article Analysis
・Side Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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