Cardioprotective Effects of Dronedarone Mediated by the Influence on the Expression of Urokinase-Type Plasminogen Activator Receptor.

Author: AkinIbrahim, BecherTobias, BorggrefeMartin, KuschykJürgen, KälschThorsten, LiebeVolker, MichelsJulia, RudicBoris, RögerSusanne, SeilerLea, StachKsenija, TrinkmannFrederik, TülümenErol, WeissChristel

Paper Details 
Original Abstract of the Article :
PURPOSE: Dronedarone is a multichannel-blocking antiarrhythmic drug for the treatment of atrial fibrillation. Observational data hypothesized a cardioprotective effect. In an in vitro endothelial cell-platelet model, we evaluated the molecular atheroprotective effects of dronedarone. METHODS: Follo...See full text at original site
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引用元:
https://doi.org/10.1159/000499526

データ提供:米国国立医学図書館(NLM)

Dronedarone: A Camel's Journey Through Cardiovascular Health

The [heart condition] of [atrial fibrillation] affects millions of people worldwide. This study, like a camel traversing a vast desert of research, investigates the potential cardioprotective effects of [dronedarone], a medication used to treat [atrial fibrillation]. The researchers, like explorers uncovering hidden secrets, examined the effects of [dronedarone] on [endothelial cells] and [platelets] in a [laboratory model].

Dronedarone: A Potential Oasis for Cardiovascular Health

The study found that [dronedarone] had complex effects on [endothelial cells] and [platelets]. While it increased [platelet activation], it also reduced the expression of [uPAR] on [endothelial cells]. This suggests that [dronedarone] may have both protective and potentially detrimental effects on the [cardiovascular system].

A Camel's Perspective on Heart Health

As a camel, I know that a strong heart is essential for traversing the desert. This study provides valuable insights into the potential of [dronedarone] for treating [atrial fibrillation]. However, it also highlights the complexity of [cardiovascular health] and the need for careful consideration of potential risks and benefits.

Dr. Camel's Conclusion

This study offers a fascinating glimpse into the intricate world of [cardiovascular health] and the complex effects of medications on the heart. While [dronedarone] shows promise for treating [atrial fibrillation], its potential benefits and risks require further investigation. As a researcher, I'm driven by the quest to understand the delicate balance within the [cardiovascular system] and to find solutions that improve heart health for all.

Date :
  1. Date Completed 2020-01-27
  2. Date Revised 2020-01-27
Further Info :

Pubmed ID

31079118

DOI: Digital Object Identifier

10.1159/000499526

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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