Long-term cardiovascular effects of vandetanib and pazopanib in normotensive rats.

Author: CarterJoanne J, CooperSamantha L, MarchJulie, WoolardJeanette

Paper Details 
Original Abstract of the Article :
Vandetanib and pazopanib are clinically available, multi-targeted inhibitors of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinases. Short-term VEGF receptor inhibition is associated with hypertension in 15%-60% of patients, which may limit t...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543457/

データ提供:米国国立医学図書館(NLM)

Cardiovascular Effects of Targeted Cancer Therapies: A Long-Term Perspective

In the ever-evolving field of cancer research, targeted therapies have emerged as powerful tools in the fight against this formidable disease. These therapies, like vandetanib and pazopanib, work by specifically targeting certain molecules involved in cancer growth and spread. However, as with any potent medication, it's essential to understand their long-term effects, especially on vital systems like the cardiovascular system. This research delves into the cardiovascular effects of vandetanib and pazopanib, examining their impact over both the short and long term. It's like observing a long desert journey, watching how the landscape changes and how the travelers adapt over time.

Sustained Cardiovascular Effects: A Journey Through Time

The study found that both vandetanib and pazopanib, while effective in targeting cancer cells, can have sustained effects on blood pressure, even after treatment has stopped. This finding is particularly important as it suggests that these drugs may pose a risk to cardiovascular health, even long after the initial treatment period. This study emphasizes the need for careful monitoring of cardiovascular health in patients receiving these therapies, particularly for those with pre-existing cardiovascular conditions.

Navigating the Risks and Benefits

This research highlights the importance of balancing the benefits of targeted therapies with the potential risks. While these treatments offer hope in the fight against cancer, it's critical to acknowledge their potential cardiovascular effects and to monitor patients closely. The study underscores the need for further research to better understand the long-term cardiovascular impact of these therapies and to develop strategies for mitigating these risks.

Dr.Camel's Conclusion

This research serves as a reminder that even the most promising medical advancements can have unforeseen consequences. It highlights the importance of long-term studies to fully understand the impact of new therapies on the human body. The findings emphasize the need for careful monitoring and management of potential risks associated with targeted cancer therapies.
Date :
  1. Date Completed 2020-02-07
  2. Date Revised 2023-10-12
Further Info :

Pubmed ID

31164986

DOI: Digital Object Identifier

PMC6543457

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Languages

English

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