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Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta-analysis of controlled studies.

Author: Appenzeller-HerzogChristian, EwaldHannah, HeeresMarlies L S, HouwenRoderick H J, MathesTim, WeissKarl Heinz

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 23 studies on Wilson disease (WD) treatment compared D-penicillamine to no treatment, zinc, trientine, or succimer. D-penicillamine was associated with lower mortality compared to no treatment, but zinc showed similar efficacy without a significant difference in mortality. While D-penicillamine may lead to more side effects and treatment discontinuations, zinc appears to be a safer alternative.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Wilson disease (WD) is a rare disorder of copper metabolism. The objective of this systematic review was to determine the comparative effectiveness and safety of common treatments of WD. METHODS: We included WD patients of any age or stage and the study drugs D-penicillamine, zin...See full text at original site
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引用元：
https://doi.org/10.1111/liv.14179

データ提供：米国国立医学図書館（NLM）

Comparing Therapies for Wilson Disease: A Comprehensive Analysis

Researchers are constantly seeking to improve the lives of individuals with rare diseases like Wilson disease (WD), a genetic disorder that disrupts copper metabolism. This study delves into the complex world of WD treatments, providing a comprehensive analysis of the comparative effectiveness and safety of common therapies. The authors conducted a systematic review and meta-analysis of controlled studies to evaluate the impact of various medications, including D-penicillamine, zinc salts, trientine, and tetrathiomolybdate, on patients with WD.

Navigating the Desert of Wilson Disease Treatment Options

The researchers found that D-penicillamine was associated with lower mortality compared to no treatment. However, it also had a greater impact on side effects and treatment discontinuations than zinc. While D-penicillamine may be effective in managing WD, its side effects can be a significant concern. It's like navigating a desert with a path that is both beautiful and treacherous - the journey might lead to a desired destination, but the risks are high.

Zinc's Promise for Wilson Disease Management

The study's findings suggest that zinc may be a safer and equally effective alternative to D-penicillamine. Zinc treatment was not associated with increased mortality and was similarly effective in preventing or reducing hepatic or neurological WD symptoms. This provides a glimmer of hope for individuals with WD seeking a safer and more tolerable treatment option.

Dr. Camel's Conclusion

This comprehensive review provides valuable insights into the effectiveness and safety of various therapies for Wilson disease. It highlights the importance of personalized treatment approaches, tailored to the specific needs and preferences of each patient. This study emphasizes the need for ongoing research to develop more effective and safer treatments for individuals with this rare and challenging condition.

Date :
  1. Date Completed 2020-10-13
  2. Date Revised 2020-10-13
Further Info :

Pubmed ID

31206982

DOI: Digital Object Identifier

10.1111/liv.14179

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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