Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss - results of an exploratory study.

Author: Ben-DorRivka R, CaiHongyi, ChungJay H, CourvilleAmber B, GharibAhmed M, GlicksmanMichael, GuerrieriGioia M, MacDonaldSandra D, MadanRitu, MaoStephanie, MartinezPedro E, MuoIjeoma M, OuwerkerkRonald, ParkSung-Jun, RodanteJustin A, WalterMary F, WalterPeter J, YangShanna B

Paper Details 
Original Abstract of the Article :
Roflumilast (Daliresp, Daxas) is a FDA-approved phosphodiesterase 4 (PDE4) inhibitor for the treatment of moderate-to-severe chronic obstructive pulmonary disease. In mice and in limited human studies, this oral medication can cause weight loss and improve insulin sensitivity. We set out to determin...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542328/

データ提供:米国国立医学図書館(NLM)

Roflumilast: A Multifaceted Solution for Prediabetes

Prediabetes is a condition where blood sugar levels are higher than normal but not yet high enough to be classified as diabetes. Imagine a camel who’s starting to feel the effects of dehydration in the desert – it’s a warning sign that action needs to be taken. This study explores the effects of roflumilast, a medication typically used for chronic obstructive pulmonary disease, on insulin sensitivity in adults with prediabetes.

The researchers examined the potential of roflumilast to improve insulin sensitivity and reduce fat mass, investigating its effects on both younger and older adults with prediabetes. It’s like studying different types of desert plants to see which ones are most effective in preventing dehydration.

A New Perspective on Prediabetes Treatment

The study revealed that roflumilast could have a positive impact on insulin sensitivity, particularly in older adults, potentially reducing their risk of developing type 2 diabetes. It’s like finding a hidden spring in the desert – a source of life and rejuvenation. The study suggests that roflumilast could be a valuable tool for managing prediabetes, particularly in individuals who may be at higher risk due to age-related factors.

Implications for Health and Lifestyle

This study offers a new perspective on prediabetes management, highlighting the potential of medications like roflumilast. It’s like a traveler who discovers a new route across the desert, leading to a better understanding of the landscape and its resources. The study emphasizes the importance of individualized treatment approaches for prediabetes, considering factors such as age and lifestyle.

Dr.Camel's Conclusion

This study shows that the world of medicine is constantly evolving, with new possibilities emerging all the time. It’s like a desert that’s constantly changing, revealing new wonders to those who explore it. By embracing innovation and exploring new approaches, we can improve the health and well-being of people with prediabetes and other conditions.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

31213865

DOI: Digital Object Identifier

PMC6542328

Related Literature

SNS
PICO Info
in preparation
Languages

English

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