Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management.

Author: EigentlerThomas K, FluckMichael, GutzmerRalf, HasselJessica C, HeinzerlingLucie, Heller-SchenckDaniela, LeipeJan, PauschingerMatthias, VogelArndt, ZimmerLisa

Paper Details 
Original Abstract of the Article :
The inhibition of the mitogen-activated protein kinases signalling pathway through combined use of BRAF and MEK inhibitors (BRAFi+MEKi) represents an established therapeutic option in patients with <i>BRAF</i>-mutated, advanced melanoma. These efficient therapies are well tolerated with mostly moder...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555610/

データ提供:米国国立医学図書館(NLM)

Navigating the Side Effects of BRAF/MEK Inhibitors

In the ever-evolving landscape of [oncology], targeted therapies are revolutionizing cancer treatment. This review delves into the use of [BRAF and MEK inhibitors (BRAFi+MEKi)] as a combined therapy for patients with BRAF-mutated melanoma. The authors provide a comprehensive overview of the safety profiles of three BRAFi+MEKi combinations, analyzing their efficacy and exploring the spectrum of adverse events associated with these potent therapies. While acknowledging the effectiveness of these therapies, the authors emphasize the need for careful monitoring and management of side effects, highlighting the importance of personalized care for patients undergoing BRAFi+MEKi treatment.

Managing Side Effects: A Balanced Approach

The review highlights that [BRAFi+MEKi] combinations are effective therapies for patients with BRAF-mutated melanoma but emphasize the need for meticulous management of side effects. The authors provide valuable insights into the common and substance-associated adverse events, offering guidance for monitoring and addressing these potential challenges.

A Guide for Personalized Care

This review serves as a valuable resource for healthcare professionals, providing insights into the management of side effects associated with [BRAFi+MEKi] therapies. By understanding the potential risks and benefits, healthcare providers can develop individualized treatment plans that optimize patient outcomes and minimize discomfort.

Dr.Camel's Conclusion

Much like a camel traversing a rugged landscape, the journey of cancer treatment can be challenging. This review, like a well-stocked caravan, offers a valuable guide for navigating the potential side effects of BRAFi+MEKi therapies. By understanding the terrain and utilizing the appropriate tools, healthcare professionals can ensure a smoother and more successful journey for their patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-01-26
Further Info :

Pubmed ID

31231568

DOI: Digital Object Identifier

PMC6555610

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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