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Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management.
Author: EigentlerThomas K, FluckMichael, GutzmerRalf, HasselJessica C, HeinzerlingLucie, Heller-SchenckDaniela, LeipeJan, PauschingerMatthias, VogelArndt, ZimmerLisa
Original Abstract of the Article :
The inhibition of the mitogen-activated protein kinases signalling pathway through combined use of BRAF and MEK inhibitors (BRAFi+MEKi) represents an established therapeutic option in patients with <i>BRAF</i>-mutated, advanced melanoma. These efficient therapies are well tolerated with mostly moder...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555610/
データ提供:米国国立医学図書館(NLM)
Navigating the Side Effects of BRAF/MEK Inhibitors
In the ever-evolving landscape of [oncology], targeted therapies are revolutionizing cancer treatment. This review delves into the use of [BRAF and MEK inhibitors (BRAFi+MEKi)] as a combined therapy for patients with BRAF-mutated melanoma. The authors provide a comprehensive overview of the safety profiles of three BRAFi+MEKi combinations, analyzing their efficacy and exploring the spectrum of adverse events associated with these potent therapies. While acknowledging the effectiveness of these therapies, the authors emphasize the need for careful monitoring and management of side effects, highlighting the importance of personalized care for patients undergoing BRAFi+MEKi treatment.
Managing Side Effects: A Balanced Approach
The review highlights that [BRAFi+MEKi] combinations are effective therapies for patients with BRAF-mutated melanoma but emphasize the need for meticulous management of side effects. The authors provide valuable insights into the common and substance-associated adverse events, offering guidance for monitoring and addressing these potential challenges.
A Guide for Personalized Care
This review serves as a valuable resource for healthcare professionals, providing insights into the management of side effects associated with [BRAFi+MEKi] therapies. By understanding the potential risks and benefits, healthcare providers can develop individualized treatment plans that optimize patient outcomes and minimize discomfort.
Dr.Camel's Conclusion
Much like a camel traversing a rugged landscape, the journey of cancer treatment can be challenging. This review, like a well-stocked caravan, offers a valuable guide for navigating the potential side effects of BRAFi+MEKi therapies. By understanding the terrain and utilizing the appropriate tools, healthcare professionals can ensure a smoother and more successful journey for their patients.
Date :
- Date Completed n.d.
- Date Revised 2021-01-26
Further Info :
Related Literature
English
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