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Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors.
Author: HuXiaoxiao, QuHaijun, ShiXiaoli, WangChuan, WangGuoping, WangLongyuan
Original Abstract of the Article :
N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide (NHPPC) is a new potential of type 5 phosphodiesterase (PDE5) inhibitors, synthesized from the avanafil analogue for the treatment of erectile dysfunction. The targets of this article were...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567057/
データ提供:米国国立医学図書館(NLM)
A New Hope for Erectile Dysfunction: NHPPC, a Potential PDE5 Inhibitor
The search for effective treatments for erectile dysfunction continues, with researchers constantly exploring new avenues to improve the lives of men struggling with this condition. This study delves into the potential of NHPPC, a novel drug, as a potential inhibitor of phosphodiesterase type 5 (PDE5), an enzyme involved in the regulation of erectile function. The researchers conducted a comprehensive series of studies to assess the pharmacokinetic, metabolic, and safety properties of NHPPC, providing valuable insights into its potential as a therapeutic agent.NHPPC: A Promising Candidate for Erectile Dysfunction
The study found that NHPPC exhibited favorable pharmacokinetic properties, indicating its potential for effective absorption and distribution within the body. Furthermore, the study revealed that NHPPC showed minimal inhibition of cytochrome P450 enzymes, suggesting a low risk of drug interactions. These findings suggest that NHPPC holds promise as a safe and effective treatment for erectile dysfunction.Navigating the Desert of Erectile Dysfunction
The journey through erectile dysfunction can be a challenging one, filled with uncertainties and potential setbacks. This study offers a glimmer of hope, suggesting that NHPPC may be a new tool in the fight against this condition. The research highlights the importance of ongoing research in developing new and effective therapies for erectile dysfunction.Dr.Camel's Conclusion
This research provides valuable insights into the potential of NHPPC as a novel and promising treatment for erectile dysfunction. The study's findings suggest that NHPPC possesses favorable pharmacokinetic properties and a low risk of drug interactions, making it a promising candidate for further development as a safe and effective therapeutic agent.Date :
- Date Completed n.d.
- Date Revised 2023-10-12
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