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Double-blind trial of R-(-)-deprenyl for the "on-off" effect complicating Parkinson's disease.

Author: DuvoisinR C, GolbeL I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Deprenyl was tested against placebo in treating 'on-off' oscillations in Parkinson's disease. Patients on deprenyl showed significant improvement in time spent in the 'on' state and were more likely to experience improvement in tremor and hypomimia during the 'on' state. Hallucinations and worsening choreoathetosis were common side effects.
Paper Details　
Original Abstract of the Article :
We performed a double-blind parallel study of deprenyl 5 mg BID vs. placebo in treatment of "on-off" oscillations complicating Parkinson's disease. After a 2-week baseline period, treatment was given for 6 weeks with weekly evaluations using the Northwestern Disability Scale and patients' hourly sel...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3123598

データ提供：米国国立医学図書館（NLM）

R-(-)-Deprenyl: A Potential Solution for 'On-Off' Fluctuations in Parkinson's Disease

In the field of [Parkinson's disease], researchers are continuously seeking ways to improve the lives of patients. This study investigates the effectiveness of R-(-)-deprenyl in treating 'on-off' fluctuations, a common complication of Parkinson's disease. The researchers conducted a double-blind parallel study, comparing the effects of deprenyl with placebo over a six-week period. Their findings demonstrate that deprenyl is moderately useful in ameliorating 'on-off' fluctuations, particularly in terms of increasing the time spent in the 'on' state. This discovery is akin to finding a hidden oasis in the vast and unpredictable desert of Parkinson's disease, offering a glimmer of hope for patients.

Deprenyl's Impact on 'On-Off' Fluctuations

Deprenyl, when compared to placebo, resulted in a significant improvement in the time spent in the 'on' state, indicating its positive impact on 'on-off' fluctuations. This finding is promising for patients who struggle with this debilitating symptom. Think of it like finding a hidden spring of water in the desert – a source of relief and improvement for those who have been enduring the harsh effects of 'on-off' fluctuations.

Managing 'On-Off' Fluctuations and Improving Quality of Life

Deprenyl, though not a cure, can help manage 'on-off' fluctuations, allowing patients to experience a greater sense of control and stability. This can translate into a higher quality of life, enabling individuals to engage in daily activities with more confidence. It's like providing a sturdy camel with a reliable water source in the desert – allowing it to traverse the challenging terrain with greater ease and assurance.

Dr.Camel's Conclusion

The study highlights the potential of R-(-)-deprenyl as a treatment option for 'on-off' fluctuations in Parkinson's disease. While further research is needed to fully understand its long-term effects, this discovery offers hope for improving the lives of patients struggling with this debilitating symptom. Imagine deprenyl as a guide, leading patients through the sometimes-unpredictable desert of Parkinson's disease, providing stability and a greater sense of well-being.
Date :
  1. Date Completed 1988-03-18
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

3123598

DOI: Digital Object Identifier

3123598

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