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Double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum.

Author: AspinallR L, DavisR E, LanzaF L, RackM F, RubinA, SwabbE A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Misoprostol was more effective than cimetidine in protecting the gastric mucosa from tolmetin-induced injury in 90 volunteers. Both drugs were highly protective in the duodenum.
Paper Details　
Original Abstract of the Article :
Ninety normal volunteers were entered into a double-blind, placebo-controlled study to compare the efficacy of misoprostol (200 micrograms q.i.d.) vs. cimetidine (300 mg q.i.d.) in protecting the gastric and duodenal mucosa from tolmetin-induced (400 mg q.i.d.) injury. After 6 days of treatment, the...See full text at original site
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引用元：
https://doi.org/10.1016/0016-5085(88)90482-9

データ提供：米国国立医学図書館（NLM）

Protecting the Gastric Mucosa: A Comparative Study of Misoprostol and Cimetidine

Gastrointestinal health is essential for our overall well-being, and this study explores the efficacy of two medications, misoprostol and cimetidine, in safeguarding the stomach and duodenum from the damaging effects of tolmetin, a nonsteroidal anti-inflammatory drug (NSAID). The researchers conducted a double-blind, placebo-controlled study, comparing the protective effects of these medications using a predetermined rating scale for mucosal injury. Their findings highlight the superior protective capabilities of misoprostol, particularly for the gastric mucosa.

Misoprostol Emerges as a More Effective Mucosal Protector

The study revealed that misoprostol demonstrated significantly higher success rates in protecting the gastric mucosa from tolmetin-induced injury compared to cimetidine and placebo. Both misoprostol and cimetidine proved highly protective in the duodenum, suggesting that these medications offer distinct protective mechanisms for different parts of the gastrointestinal tract.

Navigating NSAID Use with Prudence

This research underscores the importance of considering mucosal protection strategies when using NSAIDs, particularly those with a higher risk of gastric irritation. Misoprostol, with its superior protective effects on the stomach, could be a valuable option for patients at increased risk of NSAID-induced gastric injury. However, further research is needed to understand the long-term implications of these medications and to optimize their use for individual patients.

Dr.Camel's Conclusion

Just as a caravan needs a reliable guide to traverse the desert, patients taking NSAIDs need a protector for their delicate gastric lining. This study reveals that misoprostol, like a sturdy camel, offers superior protection against gastric injury, while cimetidine, like a nimble donkey, provides effective protection in the duodenum. This research serves as a valuable guide for both healthcare professionals and patients, promoting informed decisions about NSAID use and safeguarding gastrointestinal health.

Date :
  1. Date Completed 1988-08-12
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

3134266

DOI: Digital Object Identifier

10.1016/0016-5085(88)90482-9

Related Literature

Article Analysis
・Effects of tolmetin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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