Use of Topical and Systemic Retinoids in Solid Organ Transplant Recipients: Update and Review of the Current Literature.

Author: GoodAllison J, HeroldMitchell, LongoMaria I, NielsonColton B

Paper Details 
Original Abstract of the Article :
BACKGROUND: Solid organ transplant recipients (SOTRs) are at an increased risk of epithelial malignancies, mainly squamous cell carcinoma, and its precursor lesions such as actinic keratoses, warts, and porokeratosis, which may respond to retinoid therapy. OBJECTIVE: To review the published evidenc...See full text at original site
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引用元:
https://doi.org/10.1097/DSS.0000000000002072

データ提供:米国国立医学図書館(NLM)

Retinoids: A Powerful Weapon Against Skin Cancers in Transplant Recipients

The field of [solid organ transplant recipients (SOTRs)] faces a unique challenge in managing the [increased risk of epithelial malignancies], particularly [squamous cell carcinoma]. This review examined the [efficacy and safety] of [topical and systemic retinoids] for treating and preventing these skin cancers in SOTRs. The researchers aimed to assess the evidence for [retinoid therapy] in this vulnerable patient population.

Retinoids: A Promising Approach for SOTRs

The review found that [acitretin] had the strongest recommendation for [prophylaxis of nonmelanoma skin cancer (NMSC)] and [treatment and prophylaxis of actinic keratoses] in SOTRs. While [topical retinoids] did not show efficacy in preventing NMSC in [immunocompetent patients], they offer a valuable alternative for [managing the most common conditions] affecting SOTRs. The findings highlight the potential of [retinoids] to play a significant role in [preventing and treating skin cancers] in this high-risk group.

Protecting the Skin of Transplant Recipients

Imagine a delicate desert flower, vulnerable to the harsh elements of the sun. This review examines the use of [retinoids] as a protective shield against [skin cancers] in SOTRs. The findings underscore the importance of [early intervention] and [prophylactic strategies] to mitigate the risks of [skin cancer] in this vulnerable patient population. By harnessing the power of [retinoids], we can help protect the skin of SOTRs and ensure their overall health and well-being.

Dr. Camel's Conclusion

This review offers valuable insights into the role of retinoids in managing skin cancers in SOTRs. Acitretin stands out as a promising prophylactic agent for preventing nonmelanoma skin cancer. By understanding the efficacy and safety of different retinoid therapies, we can optimize their use in this high-risk patient population. Just as a camel adapts to the harsh desert environment, so too can we equip SOTRs with the tools they need to protect their skin and prevent the development of skin cancers.

Date :
  1. Date Completed 2020-02-25
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

31403546

DOI: Digital Object Identifier

10.1097/DSS.0000000000002072

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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