Extrahepatic Malignancies After Treatment with Direct Antiviral Agents for Chronic HCV Infection.

Author: KhouryJohad, KramskyRimma, NassarGeorge, SaadiTarek

Paper Details 
Original Abstract of the Article :
BACKGROUND: Direct antiviral agents (DAAs) have become the treatment of choice for chronic hepatitis C virus (HCV). A safety concern was raised about a possible relationship between DDAs and malignancies. We report unexpected development of extrahepatic malignancies after DAA treatment. METHODS: Fo...See full text at original site
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引用元:
https://doi.org/10.1007/s12029-019-00293-y

データ提供:米国国立医学図書館(NLM)

Direct Antiviral Agents: A Potential Link to Extrahepatic Malignancies?

The treatment of chronic hepatitis C virus (HCV) infection, like a journey through a desert, has undergone significant advancements with the advent of direct antiviral agents (DAAs). This study, like a group of desert researchers investigating the effects of new plant species, examines a potential concern: the possibility of a link between DAA treatment and the development of extrahepatic malignancies. The authors, like meticulous desert explorers, analyze data from a cohort of patients who received DAA treatment, seeking to uncover any potential associations.

DAAs and Extrahepatic Malignancies: A Need for Further Investigation

The study, like a trail leading to a hidden oasis, revealed a higher incidence of extrahepatic malignancies in patients who had received DAA treatment compared to the general population. However, the authors caution that these findings require further investigation to establish a definitive link between DAA treatment and the development of these malignancies. They emphasize the need for larger studies to clarify the potential risks and benefits associated with DAA treatment.

Health Implications and Practical Applications:

This research, like a warning sign in the desert, raises important questions about the long-term safety of DAA treatment. While DAAs have revolutionized HCV treatment, the potential for extrahepatic malignancies warrants further investigation. Healthcare providers should carefully monitor patients who receive DAA treatment and remain aware of the evolving knowledge regarding the potential risks and benefits of these medications.

Dr.Camel's Conclusion:

This study, like a desert mirage, offers a glimpse into the potential complexities associated with DAA treatment. While DAAs have proven effective in managing HCV infection, the potential link to extrahepatic malignancies requires further investigation. Continued research and careful monitoring are crucial to ensure the safety and long-term benefits of these medications for patients.

Date :
  1. Date Completed 2021-02-03
  2. Date Revised 2021-02-03
Further Info :

Pubmed ID

31407252

DOI: Digital Object Identifier

10.1007/s12029-019-00293-y

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English

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