[Arsenical resistance and difluoromethylornithine in the treatment of human African trypanosomiasis].

Author: KazyumbaG L, NkangaN, RuppolJ F, TshefuA K

Paper Details 
Original Abstract of the Article :
Human African trypanosomiasis (HAT) in Zaïre is a medical problem of first importance, particularly in endemic areas where sleeping sickness threatens about 10 millions of human beings almost the third of the whole population. Used since about forty years as the main trypanocidal drug, melarsoprol i...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3143492

データ提供:米国国立医学図書館(NLM)

Human African Trypanosomiasis: Battling the Sleeping Sickness Desert

This study takes us to the heart of [tropical medicine] where researchers are battling a relentless foe: Human African trypanosomiasis (HAT), also known as sleeping sickness. This disease, like a scorching desert sun, can slowly sap the vitality of individuals, leaving them in a state of lethargy and despair. This study explores new treatment strategies for HAT, offering hope for those affected by this debilitating condition.

New Hope in the Fight Against Sleeping Sickness: Difluoromethylornithine (DFMO)

The study highlights the challenges posed by melarsoprol, a trypanocidal drug, which has been plagued by increasing rates of treatment failures. However, the research introduces a new weapon in the fight against HAT: difluoromethylornithine (DFMO). DFMO, like a refreshing oasis in the desert, offers a new hope for individuals with resistant cases of HAT. The study reports encouraging results with DFMO, demonstrating its potential effectiveness in treating patients refractory to melarsoprol.

Seeking New Solutions for a Devastating Disease

This study underscores the need for continuous research and development of new treatment strategies for HAT. The authors emphasize the importance of finding effective treatments that are both safe and accessible to those living in endemic areas. This is like seeking out new pathways through the desert – finding innovative solutions to overcome the challenges posed by this devastating disease.

Dr.Camel's Conclusion

This research offers a beacon of hope in the battle against sleeping sickness. The emergence of DFMO as a potentially effective treatment option represents a significant step forward in the fight against this debilitating disease. The authors call for continued efforts to develop new and improved therapies, bringing relief to those living in the shadow of the sleeping sickness desert.
Date :
  1. Date Completed 1989-01-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3143492

DOI: Digital Object Identifier

3143492

Related Literature

SNS
PICO Info
in preparation
Languages

French

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