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Effects of ospemifene on genitourinary health assessed by prospective vulvar-vestibular photography and vaginal/vulvar health indices.

Author: AltomareCorrado, GoldsteinIrwin, KaunitzAndrew M, SchafferSam, SimonJames A, SoulbanGraziella, YoshidaYuki, ZhuJulie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A 12-week, double-blind, phase 3 study of 631 postmenopausal women with moderate to severe vaginal dryness showed that ospemifene significantly improved vulvovaginal health compared to placebo.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To prospectively evaluate the effects of ospemifene on the vulva and vagina in postmenopausal women using vulvar-vestibular photography and direct visual assessments. METHODS: Postmenopausal women (aged 40-80 years) with moderate to severe vaginal dryness as their most bothersome symptom...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738630/

データ提供：米国国立医学図書館（NLM）

Ospemifene's Effects on Genitourinary Health

Menopause is a natural transition that can bring about changes in the body, including vaginal dryness, which can be like a desert lacking the moisture it needs. This study investigates the effectiveness of ospemifene, a medication, in addressing this common symptom. Researchers conducted a 12-week, double-blind, multicenter phase 3 trial involving postmenopausal women experiencing moderate to severe vaginal dryness. They used vulvar-vestibular photography and other assessments to evaluate the impact of ospemifene on the vulva and vagina. The study found that ospemifene significantly improved various measures of vulvovaginal health, offering a beacon of hope for those navigating the desert of menopause.

Ospemifene's Positive Impact on Vulvovaginal Health

Ospemifene showed a positive effect on vulvovaginal health. It significantly improved overall scores for the Vulvar Imaging Assessment Scale (VIAS), Vaginal and Vulvar Health Indices (VHI and VuHI). This suggests that ospemifene can effectively combat vaginal dryness and improve the overall quality of life for postmenopausal women. This is like finding a hidden spring in the desert, providing much-needed relief.

Ospemifene's Promise for Postmenopausal Women

The results of this study provide a ray of hope for women experiencing the discomforts of menopause. Ospemifene, with its positive impact on vulvovaginal health, may offer a solution to the dryness that can be a significant challenge during this transition. This is like discovering a new irrigation system that restores life to a parched land.

Dr. Camel's Conclusion

Menopause can be like a harsh desert, but ospemifene might be the oasis we've been searching for. This study shows its potential to improve vulvovaginal health and address the challenges of vaginal dryness. By understanding the impact of menopause on the body and exploring effective treatments, we can help women navigate this transition with greater comfort and well-being.

Date :
  1. Date Completed 2020-07-16
  2. Date Revised 2023-07-21
Further Info :

Pubmed ID

31453961

DOI: Digital Object Identifier

PMC6738630

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・Effects of ospemifene
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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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