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Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor.

Author: AltFrancesca, BackesNora, BenderHannah, BrockmannMarc A, BurhenneJürgen, FaberJörg, FilipskiKatharina, FresnaisMargaux, GlaserMartin, HarterPatrick N, HuprichSabrina, LehmannNadine, NeuMarie A, ParetClaudia, PietschTorsten, RothLea, RussoAlexandra, SeidmannLarissa, SommerClemens, WagnerWolfgang, WingerterArthur

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the use of ceritinib, an off-target inhibitor of IGF1R and INSR, in a pediatric patient with an unclassified brain tumor and a *NOTCH1* germline mutation. Ceritinib showed promising results in inhibiting tumor proliferation and may be a promising drug for the treatment of IGF-driven brain tumors.
Paper Details　
Original Abstract of the Article :
The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood-brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747232/

データ提供：米国国立医学図書館（NLM）

Ceritinib: A Potential Oasis in the Desert of Brain Tumors

Imagine a brain tumor as a rogue oasis in the vast desert of the human brain, thriving on a distorted system of growth signals. The insulin-like growth factor (IGF) pathway, often disrupted in these tumors, plays a key role in their relentless growth. This study investigates the potential of ceritinib, a drug that targets this pathway, in treating a rare and challenging type of brain tumor. The study highlights the effectiveness of ceritinib in a specific case, offering hope for personalized therapies tailored to individual tumor types and pathways.

A Personalized Approach in the Desert: Ceritinib Targets the Tumor's Weakness

This case study demonstrates the potential of targeting specific pathways like the IGF pathway to combat brain tumors. The personalized approach, using ceritinib, offers a beacon of hope for patients battling these complex and often aggressive tumors.

Navigating the Desert of Brain Tumors: Seeking Expert Guidance

Brain tumors are complex and require specialized care. Consulting an oncologist, neurosurgeon, or other specialists is crucial for accurate diagnosis, treatment options, and ongoing management.

Dr.Camel's Conclusion

This study sheds light on a potential oasis in the desert of brain tumors, showcasing the power of personalized therapies. Ceritinib, a targeted drug, offers a promising approach for fighting specific tumor types by targeting the IGF pathway, a critical component in their growth. This research holds the potential to revolutionize the way we treat brain tumors, offering a beacon of hope for patients facing this challenging diagnosis.

Date :
  1. Date Completed 2020-01-21
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

31480400

DOI: Digital Object Identifier

PMC6747232

Related Literature

Article Analysis
・Side Effects of ceritinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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