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A Week of Oral Terbinafine Pulse Regimen Every Three Months to Treat all Dermatophyte Onychomycosis.

Author: PurimKatia Sheylla Malta, Queiroz-TellesFlávio, SprengerAnarosa B, SprengerFlávia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A pulse regimen of terbinafine (250 mg/day for 7 days every 3 months for 4 treatments) appears to be as effective as conventional treatment (250 mg/day for 3 months) for onychomycosis caused by dermatophytes. No significant differences in effectiveness or side effects were found between the two regimens.
Paper Details　
Original Abstract of the Article :
Terbinafine has proved to treat numerous fungal infections, including onychomycosis, successfully. Due to its liver metabolization and dependency on the cytochrome P450 enzyme complex, undesirable drug interaction are highly probable. Additionally to drug interactions, the treatment is long, rising ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787629/

データ提供：米国国立医学図書館（NLM）

A New Approach to Onychomycosis Treatment: Pulse Therapy with Terbinafine

Onychomycosis, a fungal infection of the nails, can be a stubborn and persistent condition. This study explores a novel approach to treating onychomycosis: a pulse therapy regimen of terbinafine, an antifungal medication.

Pulse Therapy: A Potential Solution to Side Effects

The researchers compared the effectiveness of three different terbinafine regimens, including the conventional daily dose, a monthly week-long pulse, and a quarterly week-long pulse. They found that the quarterly pulse regimen was as effective as the conventional regimen in treating onychomycosis while potentially reducing the risk of side effects associated with long-term continuous therapy.

Exploring New Avenues for Onychomycosis Treatment

This study offers a promising alternative for treating onychomycosis. The pulse therapy approach may provide a more convenient and potentially safer option for patients, particularly those who are concerned about side effects or long-term medication use.

Dr.Camel's Conclusion

The search for effective and safe treatments for onychomycosis is a continuous journey. This study offers a refreshing perspective by exploring the potential of pulse therapy with terbinafine. It's like discovering a hidden spring in the vast desert – a source of hope for patients seeking relief from this persistent fungal infection.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-14
Further Info :

Pubmed ID

31487828

DOI: Digital Object Identifier

PMC6787629

Related Literature

Article Analysis
・Side Effects of terbinafine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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