Paper Details 
Original Abstract of the Article :
DNA methylation have been suggested as possible mediators of long-term health effects of environmental stressors. This study aimed to evaluate the potential therapy of methylation of S-adenosyl-l-methionine (SAM) on PFOS induced trangeneral reproductive toxicity. In this study, postnatal 5d Sprague ...See full text at original site
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引用元:
https://doi.org/10.1016/j.ecoenv.2019.109579

データ提供:米国国立医学図書館(NLM)

S-Adenosyl-L-Methionine: A Potential Oasis for PFOS-Induced Transgenerational Fertility Toxicity

Perfluorooctane sulfonate (PFOS) is a persistent environmental contaminant that can have detrimental effects on human health, including reproductive toxicity. It's like a desert drought, causing lasting damage to reproductive systems. This study explores the potential of S-adenosyl-L-methionine (SAM), a naturally occurring methyl donor, to mitigate PFOS-induced transgenerational fertility toxicity in rats. The researchers exposed pregnant rats and their offspring to PFOS and then evaluated the effects of SAM supplementation. Their findings suggest that SAM could offer a potential oasis for mitigating PFOS-induced infertility. They found that SAM supplementation improved pregnancy rates in the F0 generation and increased the survival rate of offspring in the F1 generation. They also observed improvements in testicular structure and function in the F1 generation. These findings suggest that SAM could play a protective role against PFOS-induced transgenerational fertility toxicity, potentially offering a way to combat the adverse effects of this environmental contaminant.

A Promising Approach for Mitigating Environmental Toxicity

This research offers hope for mitigating the harmful effects of environmental contaminants like PFOS. The findings suggest that SAM supplementation could be a valuable tool for protecting reproductive health and mitigating the transgenerational effects of environmental toxins.

Protecting Future Generations

This study highlights the importance of protecting future generations from the harmful effects of environmental contaminants. The findings underscore the need for continued research and development of effective strategies to mitigate these risks.

Dr.Camel's Conclusion

This study is a testament to the resilience of life even in the harshest environments. It shows the potential of SAM to combat the devastating effects of PFOS, offering a beacon of hope for protecting reproductive health and safeguarding future generations from the harmful effects of environmental contaminants.

Date :
  1. Date Completed 2019-12-06
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

31505405

DOI: Digital Object Identifier

10.1016/j.ecoenv.2019.109579

SNS
PICO Info
in preparation
Languages

English

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