Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers.

Author: BeggEvan J, BeggRonald, ChambersStephen T, EvertsRichard J, GardinerSharon J, TurnidgeJohn, ZhangMei

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To measure the effect of probenecid, fasting and fed, on flucloxacillin pharmacokinetic and pharmacodynamic endpoints. METHODS: Flucloxacillin 1000 mg orally was given to 11 volunteers alone while fasting ('flucloxacillin alone'), and with probenecid 500 mg orally while fasting ('proben...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.jinf.2019.09.004

データ提供:米国国立医学図書館(NLM)

Boosting Flucloxacillin: A New Strategy in the Desert of Antibiotic Resistance

Antibiotic resistance is a growing threat, like a looming sandstorm in the desert. This study investigates the potential of probenecid, a drug known to affect the way other medications are processed in the body, to enhance the effectiveness of flucloxacillin, an antibiotic. The researchers conducted a series of experiments to examine how probenecid influences the pharmacokinetics (how the body absorbs and eliminates the drug) and pharmacodynamics (how the drug interacts with the body) of flucloxacillin. This research is like a clever camel searching for the optimal route through the desert, seeking to maximize the impact of flucloxacillin against bacterial infections.

Probenecid: A Potential Booster for Flucloxacillin

The study reveals that probenecid, when combined with flucloxacillin, significantly boosted the levels of the antibiotic in the body. This means that probenecid could potentially improve the effectiveness of flucloxacillin in fighting bacterial infections.

New Strategies for Combating Antibiotic Resistance

This research sheds light on a potential new strategy for combating antibiotic resistance. By finding ways to enhance the effectiveness of existing antibiotics, we can combat this growing threat to global health.

Dr. Camel's Conclusion

This research is a reminder of the importance of finding new ways to fight antibiotic resistance. By exploring innovative approaches like combining drugs to enhance their effectiveness, we can potentially navigate the challenging desert of antibiotic resistance and secure a brighter future for healthcare.

Date :
  1. Date Completed 2021-03-18
  2. Date Revised 2021-03-18
Further Info :

Pubmed ID

31521742

DOI: Digital Object Identifier

10.1016/j.jinf.2019.09.004

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.