Paper Details 
Original Abstract of the Article :
Abemaciclib, a selective cyclin dependent kinases 4 and 6(CDK4 & 6)inhibitor, is under development for the treatment of hormone receptor(HR)-positive, HER2-negative breast cancer. CDK4 & 6 inhibitors attenuate Rb phosphorylation resulting in a G1 arrest and tumor growth inhibition. Abemaciclib poten...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/31530780

データ提供:米国国立医学図書館(NLM)

Abemaciclib: A New Oasis in the Desert of Breast Cancer Treatment

Breast cancer, like a menacing sandstorm, threatens the health of millions worldwide. Current treatments, like a beacon in the desert, offer hope, but often come with significant side effects. This study, like a group of explorers seeking new frontiers, investigates the potential of abemaciclib, a selective cyclin-dependent kinase 4 and 6 (CDK4 & 6) inhibitor, as a novel therapy for hormone receptor (HR)-positive, HER2-negative breast cancer.

Abemaciclib: A Powerful Weapon Against Breast Cancer

The study found that abemaciclib, like a well-aimed arrow, effectively inhibits the growth of breast cancer cells, particularly those that are estrogen receptor (ER)-positive. Abemaciclib's ability to continuously inhibit CDK4 & 6, leading to senescence and apoptosis, demonstrates its potential to be a valuable tool in the fight against breast cancer.

A New Era of Breast Cancer Treatment

This research offers a beacon of hope for patients with HR-positive, HER2-negative breast cancer, suggesting that abemaciclib may offer a new and potentially more effective treatment option. The study's findings warrant further investigation, paving the way for a new era in breast cancer treatment.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the desert of breast cancer treatment. Abemaciclib, like a newly discovered oasis, holds the potential to transform the landscape of this disease, offering new and promising avenues for treatment. Further research into this compound may lead to a more effective and less toxic approach to managing this devastating illness.

Date :
  1. Date Completed 2019-10-01
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

31530780

DOI: Digital Object Identifier

31530780

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Languages

Japanese

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