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Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial.

Author: AuchusRichard J, BillerBeverly M K, CohenFredric, ElenkovaAtanaska, FeeldersRichard A, FleseriuMaria, GeerEliza B, GreenmanYona, PivonelloRosario, SalvatoriRoberto, WitekPrzemyslaw

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levoketoconazole, a ketoconazole stereoisomer, is in development for the treatment of Cushing's syndrome. This study aimed to investigate the efficacy and safety of levoketoconazole in patients with endogenous Cushing's syndrome.
Paper Details　
Original Abstract of the Article :
Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome. We aimed to investigate the efficacy and safety of levoketoconazole in patients with endogenous Cushing's s...See full text at original site
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引用元：
https://doi.org/10.1016/S2213-8587(19)30313-4

データ提供：米国国立医学図書館（NLM）

Levoketoconazole: A New Oasis for Cushing's Syndrome

This study explores the efficacy and safety of levoketoconazole, a new drug, in treating Cushing's syndrome. Cushing's syndrome is like a desert storm that can disrupt the body's delicate balance. Levoketoconazole offers a potential remedy to this storm, offering hope for restoring hormonal balance and improving the quality of life for those affected.

A Promising Remedy for Cushing's Syndrome: Levoketoconazole

This study investigates the effectiveness of levoketoconazole in managing Cushing's syndrome. The results suggest that this drug may offer a new treatment option, like finding a fresh oasis in the desert of Cushing's syndrome.

Navigating the Desert of Cushing's Syndrome: Finding a Safe Oasis

The study also focuses on the safety of levoketoconazole. Just like a traveler seeking a safe haven in the desert, researchers are carefully evaluating the potential side effects of this drug. The study provides important information for doctors and patients to make informed decisions about levoketoconazole's use in treating Cushing's syndrome.

Dr.Camel's Conclusion

This study offers a glimmer of hope for patients with Cushing's syndrome. It's like discovering a new oasis in the desert of this challenging condition, offering a potential path to better health and quality of life. Further research is needed to fully explore the benefits and safety of levoketoconazole, but this study provides a promising starting point.

Date :
  1. Date Completed 2020-05-26
  2. Date Revised 2020-05-26
Further Info :

Pubmed ID

31542384

DOI: Digital Object Identifier

10.1016/S2213-8587(19)30313-4

Related Literature

Article Analysis
・Effects of levoketoconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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