Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial.

Author: AhrenBo, Bar-DayanYosefa, BarneaMaayan, ChapnikNava, FroyOren, GanzTali, JakubowiczDaniela, LandauZohar, MenagedMiriam, MorNaomi, RazItamar, TsameretShani, WainsteinJulio

Paper Details 
Original Abstract of the Article :
In type 2 diabetes, insulin resistance and progressive β-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduct...See full text at original site
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引用元:
https://doi.org/10.2337/dc19-1142

データ提供:米国国立医学図書館(NLM)

Clock Genes, Insulin, and a Three-Meal Diet: A Novel Approach to Type 2 Diabetes Management

In the realm of [diabetes research], finding effective and safe ways to manage [type 2 diabetes] is an ongoing challenge. This study examines the potential of a [three-meal diet] to [upregulate clock gene expression], which may lead to [dose reduction of insulin] and improved [glycemic control]. The researchers conducted a [randomized clinical trial] comparing the effects of a [three-meal diet] with a [six-meal diet] in patients with [type 2 diabetes]. They discovered that [a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocaloric six-meal diet].

A New Perspective: Clock Genes and Diabetes Management

This study introduces a novel approach to [diabetes management] by focusing on [clock gene expression]. The findings suggest that [a three-meal diet] may be beneficial in [upregulating clock genes], leading to improved [insulin sensitivity] and [glycemic control].

Clocking In for Better Health: The Three-Meal Diet and Type 2 Diabetes

Think of the internal clock of your body as a camel's internal compass guiding it across the desert. This research suggests that [clock gene expression] plays a vital role in [diabetes management]. By adopting a [three-meal diet] with a [carbohydrate-rich breakfast], we may be able to synchronize our internal clocks and improve our [insulin sensitivity] and [glycemic control].

Dr.Camel's Conclusion

The findings of this study suggest that [clock genes] are a key player in [diabetes management]. By understanding and influencing these genes, we may be able to develop more effective and personalized approaches to [diabetes treatment]. It's like learning how to read the stars, to navigate the complex desert of diabetes and find a path toward better health.

Date :
  1. Date Completed 2020-07-27
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

31548244

DOI: Digital Object Identifier

10.2337/dc19-1142

Related Literature

SNS
PICO Info
in preparation
Languages

English

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