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Breast cancer drugs perturb fundamental vascular functions of endothelial cells by attenuating protein S-nitrosylation.

Author: ChatterjeeSuvro, GajalakshmiPalanivel, GiriSuvendu, KatakiaYash Tushar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Commonly used chemotherapeutic drugs like Tamoxifen citrate (TC), Capecitabine (CP), and Epirubicin (EP) are associated with cardiovascular side effects. This study investigated their impact on S-nitrosylation, a process involving nitric oxide (NO) that protects cardiovascular tissues. The results suggest that these drugs may contribute to endothelial dysfunction by reducing S-nitrosylated proteins in endothelial cells.
Paper Details　
Original Abstract of the Article :
Cardiovascular side effects of broadly used chemotherapeutic drugs such as Tamoxifen citrate (TC), Capecitabine (CP) and Epirubicin (EP) among cancer survivors are well established. Nitric oxide (NO) is known to protect cardiovascular tissues under conditions of stress. NO can act through cyclic gua...See full text at original site
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引用元：
https://doi.org/10.1111/1440-1681.13181

データ提供：米国国立医学図書館（NLM）

Breast Cancer Drugs: A Double-Edged Sword for Vascular Health

This research investigates the potential impact of widely used breast cancer drugs on the fundamental vascular functions of endothelial cells, the cells lining blood vessels. The study reveals that these drugs can disrupt protein S-nitrosylation, a vital process involved in maintaining vascular health.

The Unintended Consequences of Breast Cancer Drugs

This research explores the potential cardiovascular side effects of commonly used breast cancer drugs, revealing their ability to disrupt protein S-nitrosylation, a critical process for maintaining vascular health. The findings highlight the need for careful monitoring and potential management strategies to mitigate these risks.

The Balancing Act of Cancer Treatment and Vascular Health

Imagine the body as a vast desert landscape, where the delicate balance between cancer treatment and vascular health is a constant challenge. This research investigates the potential impact of breast cancer drugs on vascular functions, shedding light on the importance of carefully managing these drugs to minimize potential cardiovascular complications.

Dr.Camel's Conclusion

This study reveals the potential of breast cancer drugs to disrupt protein S-nitrosylation, a vital process for maintaining vascular health. The findings highlight the need for careful monitoring and potential management strategies to mitigate these risks and ensure the well-being of cancer survivors.
Date :
  1. Date Completed 2021-05-03
  2. Date Revised 2021-05-03
Further Info :

Pubmed ID

31549415

DOI: Digital Object Identifier

10.1111/1440-1681.13181

Related Literature

Article Analysis
・Side Effects of epirubicin
SNS
PICO Info
in preparation
Languages

English

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