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New Insight into the Mechanism of Anaerobic Heme Degradation.

Author: BeattieNathaniel R, LanzilottaWilliam N, MathewLiju G, PritchettClayton

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study investigates the anaerobic degradation of heme by ChuW, a protein involved in heme uptake and utilization in the enteric pathogen Escherichia coli O157:H7. The study demonstrates that the iron atom of heme is not involved in the catalytic mechanism and that S-adenosyl-l-methionine binding induces conformational changes that facilitate catalysis. The study also highlights the synergistic roles of ChuX and ChuY in enhancing ChuW's turnover rate.
Paper Details　
Original Abstract of the Article :
ChuW, ChuX, and ChuY are contiguous genes downstream from a single promoter that are expressed in the enteric pathogen <i>Escherichia coli</i> O157:H7 when iron is limiting. These genes, and the corresponding proteins, are part of a larger heme uptake and utilization operon that is common to several...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31652058

データ提供：米国国立医学図書館（NLM）

Anaerobic Heme Degradation: Unraveling the Secrets of the Microbial Desert

The microbial world is a vast and diverse desert, teeming with life that thrives in a myriad of environments. This study delves into the intricate mechanisms of anaerobic heme degradation, a process essential for iron acquisition by certain bacteria. The authors investigated the role of specific genes, ChuW, ChuX, and ChuY, in this process, examining their function and interactions in the breakdown of heme.

ChuW, ChuX, and ChuY: A Trio of Enzymes in the Heme Degradation Desert

The study reveals that ChuW, ChuX, and ChuY play crucial roles in the anaerobic degradation of heme. ChuW catalyzes the initial breakdown of heme, while ChuX and ChuY enhance its activity. Furthermore, the study discovered that ChuS, a protein previously known for its role in aerobic heme metabolism, also functions as a heme storage protein under anaerobic conditions. This research provides valuable insights into the complex mechanisms of heme degradation in bacteria.

Navigating the Microbial Desert: Understanding Essential Processes

The microbial desert is a fascinating and complex landscape, filled with organisms that have evolved unique strategies for survival. This study helps us understand the essential processes of heme degradation in certain bacteria, shedding light on their ability to acquire iron in challenging environments. This knowledge could inform the development of new antimicrobial strategies targeting these vital processes.

Dr.Camel's Conclusion

The microbial desert is a vast and enigmatic landscape, filled with organisms that have adapted to thrive in harsh and challenging conditions. This study delves into the intricate mechanisms of anaerobic heme degradation, revealing the roles of specific genes and proteins in this essential process. This research provides a glimpse into the fascinating strategies that microbes have evolved for survival in this arid landscape, furthering our understanding of the microbial world and its impact on our lives.

Date :
  1. Date Completed 2020-06-29
  2. Date Revised 2020-08-27
Further Info :

Pubmed ID

31652058

DOI: Digital Object Identifier

NIHMS1577024

SNS
PICO Info
in preparation
Languages

English

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