Paper Details

  1. Home
  2. Paper Details

Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine.

Author: AminiShohreh, BellizziAnna, BurdoTricia H, CarnevaleVincenzo, CicaleseStephanie, DonadoniMartina, GiantiEleonora, GordonJennifer, KhaliliKamel, KleinMichael L, LoomisRegina, MillerAndrew D, OzdenerMehmet H, RobinsonJake A, SariyerIlker Kudret, SteinerJoseph, WolleboHassen S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study demonstrated that rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for HIV-1 treatment, inhibits the enzymatic activity of Zika virus (ZIKV) NS5, suppresses ZIKV infection in human astrocytes, and improves clinical outcome in ZIKV-infected mice.
Paper Details　
Original Abstract of the Article :
Zika virus (ZIKV) infection is associated with microcephaly in neonates and Guillain-Barré syndrome in adults. ZIKV produces a class of nonstructural (NS) regulatory proteins that play a critical role in viral transcription and replication, including NS5, which possesses RNA-dependent RNA polymerase...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904669/

データ提供：米国国立医学図書館（NLM）

Rilpivirine: A Potential Weapon Against Zika Virus

Zika virus, a mosquito-borne virus that has wreaked havoc across the globe, poses a serious threat to human health. This study investigates the potential of rilpivirine, an antiretroviral drug used to treat HIV infection, as a treatment for Zika virus. The researchers explored the effects of rilpivirine on Zika virus infection in human brain cells and in a mouse model. Their findings offer a glimmer of hope in the fight against this debilitating virus.

Rilpivirine: A New Hope in the Zika Desert

The study found that rilpivirine effectively inhibited the activity of the Zika virus enzyme NS5, a key player in viral replication. This discovery, like finding a hidden oasis in the Zika desert, opens up new possibilities for treating this dangerous virus. Rilpivirine also showed promising results in reducing Zika virus infection in human brain cells and in preventing mortality in infected mice. These findings suggest that rilpivirine could be a valuable tool for fighting Zika virus, particularly in preventing severe complications like microcephaly.

Repurposing Drugs: A Desert of Innovation

This study demonstrates the potential of repurposing existing drugs for the treatment of emerging infectious diseases. The findings suggest that rilpivirine, a drug originally developed for HIV, could be a powerful weapon against Zika virus. This strategy, like finding a new path through a desert, could accelerate the development of new treatments for infectious diseases.

Dr. Camel's Conclusion

This study provides compelling evidence for the potential of rilpivirine as a treatment for Zika virus. The findings highlight the importance of exploring repurposed drugs for treating emerging infectious diseases. In the vast and ever-changing desert of infectious diseases, we must continuously seek new solutions and explore new avenues for treatment.
Date :
  1. Date Completed 2020-06-26
  2. Date Revised 2020-12-07
Further Info :

Pubmed ID

31653397

DOI: Digital Object Identifier

PMC6904669

Related Literature

Article Analysis
・Effects of etravirine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.