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AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia.

Author: Colturato-KidoCarina, CostaClaudia A, FerrazLetícia S, MedeirosHyllana C D, MoraesVivian W R, Paredes-GameroEdgar Julian, RodriguesTiago, TersariolIvarne L S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Promethazine may be a promising treatment for leukemia. This study demonstrated that promethazine has potent and selective cytotoxicity against leukemia cells, particularly CML cells, by activating AMPK and inhibiting PI3K/AKT/mTOR pathways, potentially triggering autophagy-associated apoptosis.
Paper Details　
Original Abstract of the Article :
Relapse and drug resistance is still major challenges in the treatment of leukemia. Promethazine, an antihistaminic phenothiazine derivative, has been used to prevent chemotherapy-induced emesis, although there is no report about its antitumor potential. Thus, we evaluated the promethazine cytotoxic...See full text at original site
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引用元：
https://doi.org/10.1016/j.cbi.2019.108888

データ提供：米国国立医学図書館（NLM）

Promethazine: A New Oasis for Chronic Myeloid Leukemia

[Chronic myeloid leukemia] is a challenging disease, like a sandstorm sweeping across the desert, that requires effective treatment options. This research, like a careful desert explorer searching for a hidden spring, explores the potential of [promethazine] as a treatment for [chronic myeloid leukemia]. The authors discovered that [promethazine] exhibits potent and selective cytotoxicity against [chronic myeloid leukemia cells], potentially offering a new approach to managing this condition.

A New Weapon in the Fight Against Chronic Myeloid Leukemia

This study suggests that [promethazine] could be a valuable weapon in the fight against [chronic myeloid leukemia], offering a potential alternative to existing therapies.

Staying Strong in the Desert of Chronic Myeloid Leukemia

While [promethazine] shows promise for [chronic myeloid leukemia] treatment, it's crucial to consult with your doctor to discuss potential side effects and to develop a personalized treatment plan.

Dr.Camel's Conclusion

This research, like a camel caravan finding a new oasis in the desert, highlights the potential of [promethazine] in the fight against [chronic myeloid leukemia]. It's a reminder that the quest for new therapies, like navigating a vast and unforgiving desert, requires persistence, innovation, and a commitment to improving patient outcomes.

Date :
  1. Date Completed 2020-02-21
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

31682805

DOI: Digital Object Identifier

10.1016/j.cbi.2019.108888

Related Literature

Article Analysis
・Side Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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