Adverse events related to abiraterone and enzalutamide treatment: analysis of the EudraVigilance database and meta-analysis of registrational phase III studies.

Author: BaldassarriValeria, BracardaSergio, De NunzioCosimo, IacovelliRoberto, LombardoRiccardo, NacchiaAntonio, SicaAngela, TemaGiorgia, TubaroAndrea, VoglinoOlivia

Paper Details 
Original Abstract of the Article :
Data from clinical trials do not always provide adequate information to judge the impact of new treatments when used in a real-world setting. The aim of our study was to analyze adverse events (AEs) associated with enzalutamide (ENZ) and abiraterone (ABI) using real-life data from the EudraVigilance...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1038/s41391-019-0182-x

データ提供:米国国立医学図書館(NLM)

Adverse Events of Abiraterone and Enzalutamide

The world of medicine is a vast and ever-evolving desert, filled with new treatments and challenges. This research examines the adverse events associated with two drugs, abiraterone and enzalutamide, used to treat prostate cancer. The authors analyzed data from the EudraVigilance database, a real-world source of information about drug safety, to identify common side effects of these drugs. Their study provides valuable insights into the potential risks associated with these treatments, guiding clinicians in making informed decisions about patient care.

Real-World Safety Data

The study found that abiraterone and enzalutamide were associated with a range of adverse events, some of which were serious. These included cardiovascular events, metabolic disorders, and liver toxicity. The study highlights the importance of carefully monitoring patients receiving these drugs for potential side effects and adjusting treatment strategies as needed. This research provides valuable information for clinicians, enabling them to make informed decisions about the use of these drugs in the context of individual patient needs and risk profiles.

Implications for Prostate Cancer Treatment and Drug Safety

The study's findings highlight the importance of ongoing monitoring and evaluation of drug safety in a real-world setting. This research provides valuable data for clinicians, enabling them to make informed decisions about the use of abiraterone and enzalutamide in treating prostate cancer. The study underscores the importance of carefully weighing the potential benefits and risks of these drugs, considering factors like patient health status and the severity of their disease. Like a camel traversing a desert, we must navigate the challenges of cancer treatment with caution and vigilance, ensuring the safety and well-being of our patients.

Dr.Camel's Conclusion

This research provides valuable insights into the real-world safety of abiraterone and enzalutamide. The study highlights the importance of carefully monitoring patients for potential side effects and making informed decisions about treatment strategies. As researchers, we must continue to explore the vast desert of medicine, seeking new oases of knowledge to improve patient safety and well-being.

Date :
  1. Date Completed 2021-03-08
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

31685981

DOI: Digital Object Identifier

10.1038/s41391-019-0182-x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.