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In vitro effects of clomiphene citrate on sperm parameters and fertilisation rate in male NMRI mice.

Author: AsgariRezvan, BakhtiariMitra, KhazaeiMozafar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Clomiphene citrate (CC) is used to treat male infertility but can have side effects. This study investigated the in vitro effects of CC on sperm parameters and fertilization rates in an IVF protocol. Results showed that low doses of CC (0.1 and 1 μg/ml) improved sperm viability, motility, and fertilization rates in vitro, suggesting potential benefits for IVF applications.
Paper Details　
Original Abstract of the Article :
Clomiphene citrate (CC), as a medication in male infertility, improves the sperm parameters in oral consumption but various detrimental side effects have been reported including testicular tumours, gynaecomastia, skin allergic reactions and ocular symptoms. Therefore, this study was designed to eval...See full text at original site
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引用元：
https://doi.org/10.1111/and.13451

データ提供：米国国立医学図書館（NLM）

Clomiphene Citrate: A New Oasis for Male Infertility?

The journey of parenthood can be a challenging one, especially for couples facing infertility. This study explores the potential of clomiphene citrate, a medication commonly used to stimulate ovulation in women, to improve sperm parameters in vitro. The researchers investigated the effects of various doses of clomiphene citrate on sperm viability, morphology, motility, and fertilization rate in male mice.

In Vitro Benefits of Clomiphene Citrate for Sperm

The study findings suggest that certain doses of clomiphene citrate may improve sperm parameters in vitro, potentially offering new avenues for treating male infertility. This is a promising result, suggesting that a hidden oasis of fertility treatment options may exist.

Navigating the Challenges of Infertility

The study highlights the importance of exploring new and innovative treatments for infertility. Just as a desert traveler needs to adapt to ever-changing conditions, couples facing infertility need to be informed about all available options and work closely with healthcare professionals to find the best path for their individual journey.

Dr.Camel's Conclusion

This research is like a camel caravan discovering a new wellspring of knowledge in the desert of reproductive health. It suggests that clomiphene citrate may hold potential as a new therapeutic option for male infertility. While more research is needed, this study offers a beacon of hope for couples struggling to conceive.

Date :
  1. Date Completed 2020-06-08
  2. Date Revised 2020-06-08
Further Info :

Pubmed ID

31696555

DOI: Digital Object Identifier

10.1111/and.13451

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Article Analysis
・Side Effects of clomiphene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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