Safety, Pharmacokinetics, and Mosquito-Lethal Effects of Ivermectin in Combination With Dihydroartemisinin-Piperaquine and Primaquine in Healthy Adult Thai Subjects.

Author: DavidsonSilas A, DayNicholas P J, DondorpArjen, HanboonkunupakarnBorimas, HoglundRichard M, JittamalaPodjanee, KobylinskiKevin C, MukakaMavuto, PantuwatanaKanchana, PhasomkusolsilSiriporn, PukrittayakameeSasithon, TarningJoel, WhiteNicholas J, WinterbergMarkus, van der PluijmRob W

Paper Details 
Original Abstract of the Article :
Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics, and mosquito-lethal effects of combinations of ivermectin, dihydroartemisinin-piperaquine, and primaquine were evaluated. Coadmi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285759/

データ提供:米国国立医学図書館(NLM)

A New Frontier in Malaria Elimination: Combining Ivermectin with Antimalarial Drugs

The fight against [malaria] is a constant battle, akin to navigating a treacherous desert landscape. This study delves into this challenging terrain, exploring a novel approach to [malaria elimination] involving the combination of [ivermectin] with [dihydroartemisinin-piperaquine and primaquine]. The researchers examine the [safety, tolerability, pharmacokinetics, and mosquito-lethal effects] of these combined therapies, seeking to pave the way for a more effective and sustainable fight against this devastating disease.

A Potential Game Changer for Malaria Control

This study, like an expedition into a desert landscape, reveals promising results regarding the safety and efficacy of combining ivermectin with antimalarial drugs. The researchers found that this combination not only [reduced parasite load] but also [increased mosquito-lethal effects], potentially offering a powerful weapon in the fight against malaria. These findings could have significant implications for [malaria control and elimination] efforts worldwide.

The Future of Malaria Control: A Multi-Pronged Approach

This research underscores the importance of [innovative strategies and multi-pronged approaches] in the fight against malaria. It highlights the potential of combining existing therapies, such as ivermectin and antimalarial drugs, to achieve greater efficacy and potentially accelerate the elimination of this disease. This study is a beacon of hope in the ongoing battle against malaria, reminding us that new and innovative solutions are constantly emerging.

Dr. Camel's Conclusion

This research, like a refreshing oasis in the desert of malaria control, offers a promising new avenue for eliminating this devastating disease. The combination of ivermectin with antimalarial drugs has shown potential in reducing parasite load and increasing mosquito-lethal effects, offering a new weapon in the fight against malaria. This study is a testament to the ongoing quest for innovative strategies and multi-pronged approaches in the battle against this global health threat.

Date :
  1. Date Completed 2021-02-16
  2. Date Revised 2021-09-15
Further Info :

Pubmed ID

31697848

DOI: Digital Object Identifier

PMC7285759

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Languages

English

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