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Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study.

Author: AeberliDaniel, BauerDouglas C, BlumManuel R, ColletTinh-Hai, Del GiovaneCinzia, FellerMartin, Gonzalez RodriguezElena, GusseklooJacobijn, HansDidier, KearneyPatricia M, LöweAxel L, MooijaartSimon, RodondiNicolas, StottDavid J, StuberMirah, WestendorpRudi G J, van HeemstDiana, van VlietNicolien A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that levothyroxine had no effect on bone health in older adults with subclinical hypothyroidism over 1 year.
Paper Details　
Original Abstract of the Article :
CONTEXT: Both thyroid dysfunction and levothyroxine (LT4) therapy have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) on bone yielded conflicting results. OBJECTIVE: To assess the effect of LT4 treatment on bone mineral density (BMD), Trabecu...See full text at original site
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引用元：
https://doi.org/10.1210/clinem/dgz058

データ提供：米国国立医学図書館（NLM）

Levothyroxine and Bone Health: A Journey Through the Desert of Thyroid Function

This study explores the potential impact of levothyroxine (LT4) treatment on bone health in older adults with subclinical hypothyroidism (SHypo). The researchers investigated the effects of LT4 therapy on bone mineral density, Trabecular Bone Score, and bone turnover markers, providing valuable insights into the complex interplay between thyroid function and skeletal health.

The Desert of Bone Health: Navigating the Effects of LT4 Therapy

The study's findings suggest that LT4 treatment does not have a significant impact on bone health in older adults with SHypo. This research provides valuable information for healthcare providers, guiding them in managing thyroid disorders in older adults while ensuring optimal skeletal health.

The Oasis of Skeletal Health: Maintaining Bone Strength Through Thyroid Management

The study emphasizes the importance of carefully monitoring bone health in individuals with thyroid disorders, regardless of treatment choices. Just as a camel relies on its strong legs to navigate the desert, we must prioritize skeletal health to maintain our strength and mobility throughout life.

Dr. Camel's Conclusion

This study provides reassurance that LT4 treatment for SHypo does not appear to negatively affect bone health in older adults. However, it underscores the importance of maintaining a healthy lifestyle and working with healthcare providers to address any potential concerns regarding skeletal health. Just as a camel adapts to the changing desert environment, we must be mindful of our own health and seek guidance from experts to maintain our well-being.

Date :
  1. Date Completed 2020-07-28
  2. Date Revised 2020-07-28
Further Info :

Pubmed ID

31702015

DOI: Digital Object Identifier

10.1210/clinem/dgz058

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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