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MnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer.

Author: FisherKurt W, GoldnerWhitney, KosmacekElizabeth A, Oberley-DeeganRebecca E, PatelAnery

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigates the use of MnTnBuOE-2-PyP, a potent scavenger of reactive oxygen species (ROS), as a radioprotector during radioactive iodine (I-131) therapy for differentiated thyroid cancer. Preclinical studies in mice suggest that MnTnBuOE-2-PyP may protect salivary glands from radiation-induced damage.
Paper Details　
Original Abstract of the Article :
Treatment of differentiated thyroid cancer often involves administration of radioactive iodine (I-131) for remnant ablation or adjuvant therapy. However, there is morbidity associated with I-131 therapy, which can result in both acute and chronic complications. Currently, there are no approved radio...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012978/

データ提供：米国国立医学図書館（NLM）

Protecting Against Radiation: A New Oasis in Thyroid Cancer Treatment

Radioactive iodine (I-131) is a powerful tool in the treatment of thyroid cancer, but it can also cause side effects, like a desert storm damaging delicate tissues. This research explores the potential of MnTnBuOE-2-PyP, a potent antioxidant, as a radioprotector to mitigate these side effects. The authors conducted experiments using mice, examining the impact of MnTnBuOE-2-PyP on the severity of I-131-induced damage. This research is like a caravan of camels, seeking to shield themselves from the harsh effects of radiation, offering a new layer of protection for those battling thyroid cancer.

MnTnBuOE-2-PyP: A Potential Shield Against Radiation Damage

The study reveals that MnTnBuOE-2-PyP may offer significant protection against the side effects of I-131 therapy. The results demonstrate that this antioxidant can help reduce the damage to salivary glands and other tissues, potentially improving the quality of life for patients undergoing this treatment.

Finding New Pathways in Cancer Treatment

This research highlights the importance of developing radioprotectors to improve the safety and efficacy of cancer therapies. By understanding the mechanisms of radiation damage and exploring the potential of antioxidants like MnTnBuOE-2-PyP, we can potentially find new ways to protect patients and enhance their treatment outcomes.

Dr. Camel's Conclusion

This research offers a glimmer of hope for those undergoing I-131 therapy for thyroid cancer. By understanding the potential benefits of radioprotectors like MnTnBuOE-2-PyP, we can potentially navigate the challenging desert of cancer treatment, minimizing side effects and maximizing treatment success.

Date :
  1. Date Completed 2021-02-08
  2. Date Revised 2021-02-08
Further Info :

Pubmed ID

31728622

DOI: Digital Object Identifier

PMC7012978

Related Literature

Article Analysis
・Side Effects of thyroid
SNS
PICO Info
in preparation
Languages

English

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