Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies.

Author: HizueMasanori, ItoYoshihiko, KadekawaKatsumi, NishijimaSaori, SugayaKimio, YamadaShizuo, YamagamiHidetomi

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To examine the effect of combining a nonselective muscarinic receptor antagonist, 5-hydroxymethyl tolterodine (an active metabolite of fesoterodine), with a β3 adrenoceptor agonist, mirabegron, in a rat model of pelvic congestion. METHODS: The rat pelvic congestion model used female Spr...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217205/

データ提供:米国国立医学図書館(NLM)

Pelvic Congestion: Finding a Solution in the Desert of Bladder Dysfunction

Navigating the desert of bladder dysfunction can be a challenging experience, particularly for those with pelvic congestion. This study explores the potential of combining fesoterodine and mirabegron, two medications with distinct mechanisms of action, to offer a more effective treatment.

A Synergistic Oasis: Combining Medications for Bladder Relief

The study found that combining fesoterodine and mirabegron showed synergistic effects in a rat model of pelvic congestion, improving bladder capacity beyond the sum of their individual effects. This is like finding two distinct oases in the desert and realizing that combining their resources creates a richer and more sustainable environment.

Navigating the Desert of Pelvic Congestion

This research offers a promising approach to treating pelvic congestion, suggesting that combining medications could be a more effective strategy. It's like discovering a new route through the desert, leading to a more comfortable and efficient journey.

Dr.Camel's Conclusion

This study presents a compelling case for combining fesoterodine and mirabegron in the treatment of pelvic congestion. Further research is needed to confirm these findings in humans, but the results provide a glimmer of hope in the desert of bladder dysfunction.

Date :
  1. Date Completed 2021-03-08
  2. Date Revised 2021-03-08
Further Info :

Pubmed ID

31758673

DOI: Digital Object Identifier

PMC7217205

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Languages

English

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