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Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies.
Author: HizueMasanori, ItoYoshihiko, KadekawaKatsumi, NishijimaSaori, SugayaKimio, YamadaShizuo, YamagamiHidetomi
Original Abstract of the Article :
OBJECTIVES: To examine the effect of combining a nonselective muscarinic receptor antagonist, 5-hydroxymethyl tolterodine (an active metabolite of fesoterodine), with a β3 adrenoceptor agonist, mirabegron, in a rat model of pelvic congestion. METHODS: The rat pelvic congestion model used female Spr...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217205/
データ提供:米国国立医学図書館(NLM)
Pelvic Congestion: Finding a Solution in the Desert of Bladder Dysfunction
Navigating the desert of bladder dysfunction can be a challenging experience, particularly for those with pelvic congestion. This study explores the potential of combining fesoterodine and mirabegron, two medications with distinct mechanisms of action, to offer a more effective treatment.
A Synergistic Oasis: Combining Medications for Bladder Relief
The study found that combining fesoterodine and mirabegron showed synergistic effects in a rat model of pelvic congestion, improving bladder capacity beyond the sum of their individual effects. This is like finding two distinct oases in the desert and realizing that combining their resources creates a richer and more sustainable environment.
Navigating the Desert of Pelvic Congestion
This research offers a promising approach to treating pelvic congestion, suggesting that combining medications could be a more effective strategy. It's like discovering a new route through the desert, leading to a more comfortable and efficient journey.
Dr.Camel's Conclusion
This study presents a compelling case for combining fesoterodine and mirabegron in the treatment of pelvic congestion. Further research is needed to confirm these findings in humans, but the results provide a glimmer of hope in the desert of bladder dysfunction.
Date :
- Date Completed 2021-03-08
- Date Revised 2021-03-08
Further Info :
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