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The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder.

Author: RoskoskiRobert

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the human fibroblast growth factor family and the development of inhibitors for their associated receptors (FGFRs). The FDA approval of erdafitinib for urinary bladder cancers may stimulate further research on FGFR-driven neoplasms.
Paper Details　
Original Abstract of the Article :
The human fibroblast growth factor family consists of 22 factors and five transmembrane receptors. Of the 22 factors, eighteen are secreted while four of them function exclusively within the cell. Four of the fibroblast growth factor receptors (FGFRs) possess intracellular protein-tyrosine kinase ac...See full text at original site
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引用元：
https://doi.org/10.1016/j.phrs.2019.104567

データ提供：米国国立医学図書館（NLM）

Fibroblast Growth Factor Receptor (FGFR) Inhibitors: A Camel's Journey Through the Desert of Cancer Treatment

Cancer, a formidable disease that can disrupt the delicate balance of our bodies, is like a relentless sandstorm sweeping across the desert of our health. This research explores the potential of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors as a new weapon in the fight against cancer. It's like discovering a hidden oasis within the vast desert of cancer research, seeking to find new ways to combat this challenging disease.

A New Oasis of Hope: FGFR Inhibitors Show Promise

The research highlights the role of FGFR gene alterations in various cancers, including those of the urinary bladder. It also discusses the development of FGFR antagonists, such as erdafitinib, which have shown promise in treating these cancers. This is like finding a hidden spring in the desert, offering a source of hope for those battling this disease.

Navigating the Desert of Cancer: A Camel's Perspective

This research underscores the importance of targeting specific pathways and mechanisms involved in cancer growth. It highlights the potential of FGFR inhibitors to provide a new avenue for treating various cancers, including those of the urinary bladder. Just as a camel caravan relies on a skilled guide to navigate the treacherous desert terrain, researchers are continually seeking to develop more effective and targeted treatments to combat this challenging disease.

Dr. Camel's Conclusion

This research explores the promising potential of FGFR inhibitors as a new weapon in the fight against cancer. It's like discovering a hidden oasis within the vast desert of cancer research, offering a source of hope and a new path towards more effective treatments. As researchers, we must continue to explore and develop innovative therapies to combat cancer, seeking to provide patients with a brighter future and a chance for a healthy life.

Date :
  1. Date Completed 2021-01-05
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

31770593

DOI: Digital Object Identifier

10.1016/j.phrs.2019.104567

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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