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Sonic Hedgehog Pathway Inhibition in the Treatment of Advanced Basal Cell Carcinoma.

Author: LaskGary, LeavittErica, MartinStephanie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of Sonic hedgehog (Shh) pathway inhibitors for advanced basal cell carcinoma (BCC). Vismodegib and sonidegib are FDA-approved for advanced BCCs and have been used for prevention and as neoadjuvant therapy.
Paper Details　
Original Abstract of the Article :
Advanced basal cell carcinoma (BCC) represents a small proportion of BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence risk, and excessive morbidity. Implication of the Sonic hedgehog (Shh) pathway in the development of BCC has led to the development of system...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://doi.org/10.1007/s11864-019-0683-9

データ提供：米国国立医学図書館（NLM）

Sonic Hedgehog Pathway Inhibition in the Treatment of Advanced Basal Cell Carcinoma

The field of cancer research is a continuous journey through a challenging desert, where researchers are constantly seeking new weapons against this formidable foe. This study focuses on a specific type of cancer, advanced basal cell carcinoma (BCC), and explores the potential of targeting the Sonic hedgehog (Shh) pathway as a therapeutic strategy. It's like uncovering a hidden oasis of knowledge, revealing a new approach to combating this challenging disease.

A New Oasis in the Desert of Advanced Basal Cell Carcinoma

The study highlights the potential of Shh pathway inhibitors, such as vismodegib and sonidegib, in treating advanced BCC. These drugs offer a new avenue for patients with this challenging condition, providing a potential lifeline for those who have not responded to traditional therapies. It's like finding a hidden spring in the desert, offering a source of hope and relief.

Navigating the Sands of Cancer Treatment

This research showcases the importance of targeting specific pathways in cancer treatment, like navigating a desert landscape with a precise map. The study emphasizes the ongoing need for research and development to find new and more effective treatments for advanced BCC. It's a reminder that the journey through the desert of cancer is long and challenging, requiring continuous exploration and innovation.

Dr.Camel's Conclusion

This research on Sonic hedgehog pathway inhibition in the treatment of advanced basal cell carcinoma highlights the importance of understanding and targeting specific pathways in cancer treatment. The development of Shh pathway inhibitors offers a new and promising approach for patients with this challenging condition. It's like finding a new route through the desert of cancer, offering a potential oasis of hope and relief.

Date :
  1. Date Completed 2020-08-21
  2. Date Revised 2020-08-21
Further Info :

Pubmed ID

31773379

DOI: Digital Object Identifier

10.1007/s11864-019-0683-9

Related Literature

Article Analysis
・Side Effects of sonidegib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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